The relationship between negative symptoms and depression in schizophrenia: A systematic review

C. R. Krynicki*, R. Upthegrove, J. F.W. Deakin, T. R.E. Barnes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)
640 Downloads (Pure)


Objective: To provide an update on the evidence base for the nature of the relationship between negative symptoms and depressive features in people with schizophrenia, and propose new models that reflect their complex relationship. Method: A systematic review following PRISMA guidelines. A total of 2210 articles were identified from EMBASE, PsychInfo and MEDLINE, and further two articles were hand-searched from references. Twenty-seven met inclusion criteria and were included in the review. Results: In schizophrenia, primary evidence suggests symptoms of low mood, suicidal ideation and pessimism have more specificity for depression whereas alogia and blunted affect may have more specificity as negative symptoms. Anhedonia, anergia and avolition may be common to both. Conclusion: It may be possible to further distinguish depressive features from negative symptoms in schizophrenia when detailed phenomenology is considered. However, in a proposed dimensional model, these two domains continue to share certain phenomena, highlighting their close relationship.

Original languageEnglish
Pages (from-to)380-390
JournalActa Psychiatrica Scandinavica
Issue number5
Early online date13 Mar 2018
Publication statusE-pub ahead of print - 13 Mar 2018


  • Depression
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health


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