TY - JOUR
T1 - The relationship between aortic aneurysm sac thrombus volume on coagulation, fibrinolysis and platelet activity.
AU - Davies, Robert
AU - Abdelhamid, Mohamed
AU - Vohra, Rajiv
AU - Bradbury, Andrew
AU - Adam, Donald
PY - 2012/4/10
Y1 - 2012/4/10
N2 - AIM: Abdominal aortic aneurysm (AAA) is associated with chronic mural inflammation and a pro-thrombotic diathesis. It has been suggested that both may be related to biologically active intra-sac thrombus. The aim of this study was to examine the relationship between thrombin generation, fibrinolysis, platelet activity and AAA sac thrombus volume. METHODS: 30 patients (29 men) of median (IQR) age 75 (71-82) years with an infra-renal AAA >5.5cm in antero-posterior diameter were prospectively studied. AAA, lumen and thrombus volumes were calculated using a CT workstation (Vitrea). Plasma thrombin-antithrombin (TAT), plasminogen activator inhibitor (PAI)-1, and soluble (s) P-selectin were measured as biomarkers of coagulation, fibrinolysis and platelet activity, respectively RESULTS: Median (IQR) AAA total, lumen and thrombus volumes were 188 (147-247) cm(3), 80 (54.3-107) cm(3) and 97.6 (63-127) cm(3) respectively. TAT levels were significantly higher (median, QR, 7.15 [4.7-31.3] μg/L, p=
AB - AIM: Abdominal aortic aneurysm (AAA) is associated with chronic mural inflammation and a pro-thrombotic diathesis. It has been suggested that both may be related to biologically active intra-sac thrombus. The aim of this study was to examine the relationship between thrombin generation, fibrinolysis, platelet activity and AAA sac thrombus volume. METHODS: 30 patients (29 men) of median (IQR) age 75 (71-82) years with an infra-renal AAA >5.5cm in antero-posterior diameter were prospectively studied. AAA, lumen and thrombus volumes were calculated using a CT workstation (Vitrea). Plasma thrombin-antithrombin (TAT), plasminogen activator inhibitor (PAI)-1, and soluble (s) P-selectin were measured as biomarkers of coagulation, fibrinolysis and platelet activity, respectively RESULTS: Median (IQR) AAA total, lumen and thrombus volumes were 188 (147-247) cm(3), 80 (54.3-107) cm(3) and 97.6 (63-127) cm(3) respectively. TAT levels were significantly higher (median, QR, 7.15 [4.7-31.3] μg/L, p=
U2 - 10.1016/j.thromres.2012.03.018
DO - 10.1016/j.thromres.2012.03.018
M3 - Article
C2 - 22497884
JO - Thrombosis Research
JF - Thrombosis Research
ER -