The relationship between abdominal aortic aneurysm distensbility and serum markers of elastin and collagin metabolism

KA Wilson; JS Lindholt; PR Hoskins; L Heickendorff; S Vammen; Andrew Bradbury

doi:10.1053/ejvs.2001.1303

The relationship between abdominal aortic aneurysm distensbility and serum markers of elastin and collagin metabolism

KA Wilson, JS Lindholt, PR Hoskins, L Heickendorff, S Vammen, Andrew Bradbury

Cardiovascular Sciences

Research output: Contribution to journal › Article

59 Citations (Scopus)

Abstract

Background: abdominal aortic aneurysm (AAA) distensibility may be an independent predictor of growth and rupture, possibly because it reflects changes in aortic wall structure and composition. Aim: to determine whether AAA distensibility is related to circulating markers of elastin and collagen metabolism. Methods: sixty-two male patients of median age (IQR) 68 (65-72) years with asymptomatic AAA of median (IQR) diameter 42 (37-45) mm were prospectively studied. Pressure-strain elastic modulus (Epi and stiffness (beta) were measured using an ultrasonic echo-tracker (Diamove). Serum elastin peptides (SEP), plasma elastin-alpha (1)-antitrypsin complex (E-AT), procollagen III-N-terminal propeptide (PIIINP) were measured by enzyme-linked immunoassay. Results: age and smoking adjusted Ep and beta were significantly inversely related to SEP (r = -0.33 and r = -0.31 respectively, both p <0.02) and E-AT (r = -0.27 and r = -0.27 respectively, both p

Original language	English
Pages (from-to)	175-178
Number of pages	4
Journal	European Journal of Vascular and Endovascular Surgery
Volume	21
DOIs	https://doi.org/10.1053/ejvs.2001.1303
Publication status	Published - 1 Feb 2001

Keywords

elasticity
elastolysis
collagenolysis
aneurysm

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10.1053/ejvs.2001.1303

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title = "The relationship between abdominal aortic aneurysm distensbility and serum markers of elastin and collagin metabolism",

abstract = "Background: abdominal aortic aneurysm (AAA) distensibility may be an independent predictor of growth and rupture, possibly because it reflects changes in aortic wall structure and composition. Aim: to determine whether AAA distensibility is related to circulating markers of elastin and collagen metabolism. Methods: sixty-two male patients of median age (IQR) 68 (65-72) years with asymptomatic AAA of median (IQR) diameter 42 (37-45) mm were prospectively studied. Pressure-strain elastic modulus (Epi and stiffness (beta) were measured using an ultrasonic echo-tracker (Diamove). Serum elastin peptides (SEP), plasma elastin-alpha (1)-antitrypsin complex (E-AT), procollagen III-N-terminal propeptide (PIIINP) were measured by enzyme-linked immunoassay. Results: age and smoking adjusted Ep and beta were significantly inversely related to SEP (r = -0.33 and r = -0.31 respectively, both p <0.02) and E-AT (r = -0.27 and r = -0.27 respectively, both p",

keywords = "elasticity, elastolysis, collagenolysis, aneurysm",

author = "KA Wilson and JS Lindholt and PR Hoskins and L Heickendorff and S Vammen and Andrew Bradbury",

year = "2001",

month = feb,

day = "1",

doi = "10.1053/ejvs.2001.1303",

language = "English",

volume = "21",

pages = "175--178",

journal = "European Journal of Vascular and Endovascular Surgery",

publisher = "Elsevier",

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TY - JOUR

T1 - The relationship between abdominal aortic aneurysm distensbility and serum markers of elastin and collagin metabolism

AU - Wilson, KA

AU - Lindholt, JS

AU - Hoskins, PR

AU - Heickendorff, L

AU - Vammen, S

AU - Bradbury, Andrew

PY - 2001/2/1

Y1 - 2001/2/1

N2 - Background: abdominal aortic aneurysm (AAA) distensibility may be an independent predictor of growth and rupture, possibly because it reflects changes in aortic wall structure and composition. Aim: to determine whether AAA distensibility is related to circulating markers of elastin and collagen metabolism. Methods: sixty-two male patients of median age (IQR) 68 (65-72) years with asymptomatic AAA of median (IQR) diameter 42 (37-45) mm were prospectively studied. Pressure-strain elastic modulus (Epi and stiffness (beta) were measured using an ultrasonic echo-tracker (Diamove). Serum elastin peptides (SEP), plasma elastin-alpha (1)-antitrypsin complex (E-AT), procollagen III-N-terminal propeptide (PIIINP) were measured by enzyme-linked immunoassay. Results: age and smoking adjusted Ep and beta were significantly inversely related to SEP (r = -0.33 and r = -0.31 respectively, both p <0.02) and E-AT (r = -0.27 and r = -0.27 respectively, both p

AB - Background: abdominal aortic aneurysm (AAA) distensibility may be an independent predictor of growth and rupture, possibly because it reflects changes in aortic wall structure and composition. Aim: to determine whether AAA distensibility is related to circulating markers of elastin and collagen metabolism. Methods: sixty-two male patients of median age (IQR) 68 (65-72) years with asymptomatic AAA of median (IQR) diameter 42 (37-45) mm were prospectively studied. Pressure-strain elastic modulus (Epi and stiffness (beta) were measured using an ultrasonic echo-tracker (Diamove). Serum elastin peptides (SEP), plasma elastin-alpha (1)-antitrypsin complex (E-AT), procollagen III-N-terminal propeptide (PIIINP) were measured by enzyme-linked immunoassay. Results: age and smoking adjusted Ep and beta were significantly inversely related to SEP (r = -0.33 and r = -0.31 respectively, both p <0.02) and E-AT (r = -0.27 and r = -0.27 respectively, both p

KW - elasticity

KW - elastolysis

KW - collagenolysis

KW - aneurysm

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U2 - 10.1053/ejvs.2001.1303

DO - 10.1053/ejvs.2001.1303

M3 - Article

C2 - 11237793

VL - 21

SP - 175

EP - 178

JO - European Journal of Vascular and Endovascular Surgery

JF - European Journal of Vascular and Endovascular Surgery

ER -

The relationship between abdominal aortic aneurysm distensbility and serum markers of elastin and collagin metabolism

Abstract

Keywords

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