The regulation of bacterial transcription initiation

Research output: Contribution to journalReview article

635 Citations (Scopus)


Bacteria use their genetic material with great effectiveness to make the right products in the correct amounts at the appropriate time. Studying bacterial transcription initiation in Escherichia coli has served as a model for understanding transcriptional control throughout all kingdoms of life. Every step in the pathway between gene and function is exploited to exercise this control, but for reasons of economy, it is plain that the key step to regulate is the initiation of RNA-transcript formation.
Original languageEnglish
Pages (from-to)57-65
Number of pages9
JournalNature Reviews Microbiology
Publication statusPublished - 1 Jan 2004


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