The protein kinase C agonist PEP005 (ingenol 3-angelate) in the treatment of human cancer: a balance between efficacy and toxicity

Medicine & Life Sciences

• 3-ingenyl angelate 84%
• Protein Kinase C 45%
• Euphorbia 30%
• Skin Neoplasms 20%
• T-Lymphocytes 17%
• Melanoma 16%
• Neoplasms 15%
• Keratosis 13%
• Diterpenes 13%
• Warts 12%
• Lymphopenia 11%
• Neutrophil Infiltration 11%
• Nuclear Envelope 10%
• Complex Mixtures 10%
• Esters 9%
• Isoenzymes 9%
• Acute Myeloid Leukemia 9%
• Chemokines 9%
• Cytoplasm 7%
• Therapeutics 7%
• Necrosis 7%
• Animal Models 6%
• Cytokines 6%
• Cell Line 5%
• Inflammation 5%
• Drug Therapy 5%
• Antibodies 5%
• Skin 5%
• In Vitro Techniques 4%
• Pharmaceutical Preparations 4%

Chemistry

• Protein Kinase C Agonist 100%
• Ingenol 85%
• Lymphopenia 23%
• Protein 20%
• Diterpene 13%
• Application 7%
• Ester 7%
• Drug 6%