The Properties of HPMC: PEO Extended Release Hydrophilic Matrices and their Response to Ionic Environments

Anran Hu, Chen Chen, Michael D. Mantle*, Bettina Wolf, Lynn F. Gladden, Ali Rajabi-Siahboomi, Shahrzad Missaghi, Laura Mason, Colin D. Melia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Purpose: Investigate the extended release behaviour of compacts containing mixtures of hydrophilic HPMC and PEO in hydrating media of differing ionic strengths. 


Methods: The extended release behaviour of various HPMC:PEO compacts was investigated using dissolution testing, confocal microscopy and magnetic resonance imaging, with respect to polymer ratio and ionic strength of the hydrating media. 


Results: Increasing HPMC content gave longer extended release times, but a greater sensitivity to high ionic dissolution environments. Increasing PEO content reduced this sensitivity. The addition of PEO to a predominantly HPMC matrix reduced release rate sensitivity to high ionic environments. Confocal microscopy of early gel layer development showed the two polymers appeared to contribute independently to gel layer structure whilst together forming a coherent and effective diffusion barrier. There was some evidence that poorly swollen HPMC particles added a tortuosity barrier to the gel layer in high ionic strength environments, resulting in prolonged extended release. MRI provides unique, non-invasive spatially resolved information from within the HPMC:PEO compacts that furthers our understanding of USP 1 and USP 4 dissolution data. 


Conclusions: Confocal microscopy and MRI data show that combinations of HPMC and PEO have advantageous extended release properties, in comparison with matrices containing a single polymer.

Original languageEnglish
Pages (from-to)941-956
Number of pages16
JournalPharmaceutical Research
Volume34
Issue number5
Early online date15 Sep 2016
DOIs
Publication statusPublished - 1 May 2017

Keywords

  • confocal fluorescence microscopy
  • digital imaging
  • dissolution
  • HPMC
  • hydrophilic matrix
  • MRI
  • PEO
  • polymer mixtures

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)

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