The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader–Willi Syndromes

R. Royston, C. Oliver, P. Howlin, A. Dosse, P. Armitage, J. Moss, J. Waite

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Abstract

Psychopathology is prevalent in Williams (WS), fragile X (FXS) and Prader–Willi (PWS) syndromes. However, little is known about the potential correlates of psychopathology in these groups. A questionnaire study was completed by 111 caregivers of individuals with WS (n = 35); FXS (n = 50) and PWS (n = 26). Mean age was 26 years (range 12–57 years); 74 (67%) were male. Multiple regression analyses indicated that higher rates of health problems and sensory impairments predicted higher psychopathology in WS (p < .0001). In PWS, poorer adaptive ability predicted higher overall psychiatric disturbance (p = .001), generalised anxiety (p = .006) and hyperactivity (p = .003). There were no significant predictors in FXS. This study highlights dissociations in the potential risk markers of psychopathology between genetic syndromes. Implications for intervention are discussed.
Original languageEnglish
Pages (from-to)1-11
JournalJournal of Autism and Developmental Disorders
Early online date4 Dec 2019
DOIs
Publication statusE-pub ahead of print - 4 Dec 2019

Keywords

  • Williams syndrome
  • Prader–Willi syndrome
  • Fragile X syndrome
  • Psychopathology
  • Correlates

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