TY - JOUR
T1 - The prevalence of hyperhomocysteinemia, methylene tetrahydrofolate reductase C677T mutation, vitamin B12 and folate deficiency in patients with chronic venous insufficiency
AU - Sam, RC
AU - Burns, PJ
AU - Hobbs, S
AU - Marshall, Timothy
AU - Silverman, Stanley
AU - Bradbury, Andrew
AU - Wilmink, Antonius
PY - 2003/11/1
Y1 - 2003/11/1
N2 - INTRODUCTION: Hyperhomocysteinemia (HHcy) is a risk factor for venous thromboembolism, which in turn is a major cause of chronic venous insufficiency. HHcy may be more common in patients with chronic venous insufficiency, but the cause is unknown. METHODS: One hundred hospital outpatients (52 women; median age, 66.5 years [interquartile range, 53-77 years] with venous disease C(2-6) underwent assessment of serum vitamin B(12) and folate concentration, plasma Hcy concentration, and C677T methylene tetrahydrofolate reductase (MTHR) homozygosity with polymerase chain reaction. HHcy was defined as greater than 15 micromol/L, the 95th centile of the normal range. RESULTS: CEAP classification was C(2) in 39 patients, C(3) in 10 patients, C(4) in 13 patients, C(5) in 15 patients, and C(6) in 23 patients, with median Hcy concentration 11.6, 11.5, 12.5, 15.1, and 18.1 micromol/L, respectively (Kruskall-Wallis test, P
AB - INTRODUCTION: Hyperhomocysteinemia (HHcy) is a risk factor for venous thromboembolism, which in turn is a major cause of chronic venous insufficiency. HHcy may be more common in patients with chronic venous insufficiency, but the cause is unknown. METHODS: One hundred hospital outpatients (52 women; median age, 66.5 years [interquartile range, 53-77 years] with venous disease C(2-6) underwent assessment of serum vitamin B(12) and folate concentration, plasma Hcy concentration, and C677T methylene tetrahydrofolate reductase (MTHR) homozygosity with polymerase chain reaction. HHcy was defined as greater than 15 micromol/L, the 95th centile of the normal range. RESULTS: CEAP classification was C(2) in 39 patients, C(3) in 10 patients, C(4) in 13 patients, C(5) in 15 patients, and C(6) in 23 patients, with median Hcy concentration 11.6, 11.5, 12.5, 15.1, and 18.1 micromol/L, respectively (Kruskall-Wallis test, P
UR - http://www.scopus.com/inward/record.url?scp=0242408365&partnerID=8YFLogxK
U2 - 10.1016/S0741-5214(03)00923-6
DO - 10.1016/S0741-5214(03)00923-6
M3 - Article
C2 - 14603192
VL - 38
SP - 904
EP - 908
JO - Journal of Vascular Surgery
JF - Journal of Vascular Surgery
IS - 5
ER -