The PI3K p110delta is required for down-regulation of RAG expression in immature B cells

Miriam Llorian, Zania Stamataki, Susan Hill, Martin Turner, Inga-Lill Mårtensson

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


At the immature B cell stage the BCR signals the down-regulation of the RAG genes and Ig L chain (LC) allelic and isotype exclusion. The signaling pathway that regulates these events is poorly characterized. We demonstrate that immature B cells from mice deficient in the PI3K catalytic subunit p110delta fail to suppress RAG expression and inappropriately recombine kappa and lambda LC loci. In addition, in the presence of the autoantigen, clonal deletion and receptor editing still takes place, demonstrating that these processes are independent of p110delta. These results demonstrate a role for p110delta in the regulation of RAG gene expression and thereby LC allelic/isotype exclusion.
Original languageEnglish
Pages (from-to)1981-5
Number of pages5
JournalJournal of Immunology
Issue number4
Publication statusPublished - 15 Feb 2007


  • Animals
  • Homeodomain Proteins
  • Immunoglobulin Light Chains
  • DNA-Binding Proteins
  • Immunoglobulin Class Switching
  • Immunoglobulin kappa-Chains
  • Mice
  • B-Lymphocytes
  • Autoantigens
  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins c-bcr
  • Mice, Knockout
  • Down-Regulation
  • Clonal Deletion


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