The Pco proteins are involved in periplasmic copper handling in Escherichia coli

SM Lee; G Grass; C Rensing; SR Barrett; CJD Yates; Jivko Stoyanov; Nigel Brown

doi:10.1016/S0006-291X(02)00726-X

The Pco proteins are involved in periplasmic copper handling in Escherichia coli

SM Lee, G Grass, C Rensing, SR Barrett, CJD Yates, Jivko Stoyanov, Nigel Brown

Biosciences

Research output: Contribution to journal › Article

82 Citations (Scopus)

Abstract

The interactions between the plasmid-borne copper resistance determinant, pco, and the main copper export system in Escherichia coli have been investigated and no direct interaction has been found. The PcoE and PcoC proteins are periplasmic and PcoC binds one Cu ion per protein molecule. PcoA is also periplasmic and can substitute for the chromosomally encoded CueO protein. The pco determinant is proposed to exert its effect through periplasmic handling of excess copper ions and to increase the level of resistance to copper ions above that conferred by copA alone.

Original language	English
Pages (from-to)	616-620
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	295
Issue number	3
DOIs	https://doi.org/10.1016/S0006-291X(02)00726-X
Publication status	Published - 19 Jul 2002

Keywords

Cu(II)
metal homeostasis
copper resistance
cop
TAT

Access to Document

10.1016/S0006-291X(02)00726-X

Cite this

@article{d0aef68b1a0d4a50a412bb1634574a7d,

title = "The Pco proteins are involved in periplasmic copper handling in Escherichia coli",

abstract = "The interactions between the plasmid-borne copper resistance determinant, pco, and the main copper export system in Escherichia coli have been investigated and no direct interaction has been found. The PcoE and PcoC proteins are periplasmic and PcoC binds one Cu ion per protein molecule. PcoA is also periplasmic and can substitute for the chromosomally encoded CueO protein. The pco determinant is proposed to exert its effect through periplasmic handling of excess copper ions and to increase the level of resistance to copper ions above that conferred by copA alone.",

keywords = "Cu(II), metal homeostasis, copper resistance, cop, TAT",

author = "SM Lee and G Grass and C Rensing and SR Barrett and CJD Yates and Jivko Stoyanov and Nigel Brown",

year = "2002",

month = jul,

day = "19",

doi = "10.1016/S0006-291X(02)00726-X",

language = "English",

volume = "295",

pages = "616--620",

journal = "Biochemical and Biophysical Research Communications",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - The Pco proteins are involved in periplasmic copper handling in Escherichia coli

AU - Lee, SM

AU - Grass, G

AU - Rensing, C

AU - Barrett, SR

AU - Yates, CJD

AU - Stoyanov, Jivko

AU - Brown, Nigel

PY - 2002/7/19

Y1 - 2002/7/19

N2 - The interactions between the plasmid-borne copper resistance determinant, pco, and the main copper export system in Escherichia coli have been investigated and no direct interaction has been found. The PcoE and PcoC proteins are periplasmic and PcoC binds one Cu ion per protein molecule. PcoA is also periplasmic and can substitute for the chromosomally encoded CueO protein. The pco determinant is proposed to exert its effect through periplasmic handling of excess copper ions and to increase the level of resistance to copper ions above that conferred by copA alone.

AB - The interactions between the plasmid-borne copper resistance determinant, pco, and the main copper export system in Escherichia coli have been investigated and no direct interaction has been found. The PcoE and PcoC proteins are periplasmic and PcoC binds one Cu ion per protein molecule. PcoA is also periplasmic and can substitute for the chromosomally encoded CueO protein. The pco determinant is proposed to exert its effect through periplasmic handling of excess copper ions and to increase the level of resistance to copper ions above that conferred by copA alone.

KW - Cu(II)

KW - metal homeostasis

KW - copper resistance

KW - cop

KW - TAT

UR - http://www.scopus.com/inward/record.url?scp=0036314736&partnerID=8YFLogxK

U2 - 10.1016/S0006-291X(02)00726-X

DO - 10.1016/S0006-291X(02)00726-X

M3 - Article

C2 - 12099683

VL - 295

SP - 616

EP - 620

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

The Pco proteins are involved in periplasmic copper handling in Escherichia coli

Abstract

Keywords

Access to Document

Fingerprint

Cite this