TY - JOUR
T1 - The natural history of myocardium awaiting revascularisation in patients with impaired left ventricular function
AU - Pitt, MPI
AU - Dutka, DP
AU - Pagano, Domenico
AU - Camici, PG
AU - Bonser, Robert
PY - 2004/3/1
Y1 - 2004/3/1
N2 - AIMS: Our aim was to follow changes in myocardial function and physiology in patients awaiting coronary artery bypass surgery (CABG) and relate changes to post-revascularisation functional response. METHODS AND RESULTS: In 21 patients with CAD and LV dysfunction, myocardial glucose utilisation (MGU) and blood flow (MBF) were measured with positron emission tomography using F-18-fluorodeoxyglucose and oxygen-15-labelled water. Left ventricular function, MGU, and MBF were re-assessed after one year, immediately prior to CABG. At baseline, dysfunctional myocardium displayed a reduction in MGU, hyperaemic MBF, and coronary vasodilator reserve (CVR) compared to normally functioning muscle. In the year preceding CABG, the overall wall motion score index increased (2.09 +/- 0.65 vs. 2.3 +/- 0.7, p=0.0001) and the LV ejection fraction decreased (30.6 +/- 11.1% vs. 27.3 +/- 11.5%, p
AB - AIMS: Our aim was to follow changes in myocardial function and physiology in patients awaiting coronary artery bypass surgery (CABG) and relate changes to post-revascularisation functional response. METHODS AND RESULTS: In 21 patients with CAD and LV dysfunction, myocardial glucose utilisation (MGU) and blood flow (MBF) were measured with positron emission tomography using F-18-fluorodeoxyglucose and oxygen-15-labelled water. Left ventricular function, MGU, and MBF were re-assessed after one year, immediately prior to CABG. At baseline, dysfunctional myocardium displayed a reduction in MGU, hyperaemic MBF, and coronary vasodilator reserve (CVR) compared to normally functioning muscle. In the year preceding CABG, the overall wall motion score index increased (2.09 +/- 0.65 vs. 2.3 +/- 0.7, p=0.0001) and the LV ejection fraction decreased (30.6 +/- 11.1% vs. 27.3 +/- 11.5%, p
UR - http://www.scopus.com/inward/record.url?scp=1942424797&partnerID=8YFLogxK
U2 - 10.1016/j.ehj.2004.01.016
DO - 10.1016/j.ehj.2004.01.016
M3 - Article
C2 - 15039130
SN - 1522-9645
VL - 25
SP - 500
EP - 507
JO - European Heart Journal
JF - European Heart Journal
ER -