The natural history of myocardium awaiting revascularisation in patients with impaired left ventricular function

MPI Pitt, DP Dutka, Domenico Pagano, PG Camici, Robert Bonser

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

AIMS: Our aim was to follow changes in myocardial function and physiology in patients awaiting coronary artery bypass surgery (CABG) and relate changes to post-revascularisation functional response. METHODS AND RESULTS: In 21 patients with CAD and LV dysfunction, myocardial glucose utilisation (MGU) and blood flow (MBF) were measured with positron emission tomography using F-18-fluorodeoxyglucose and oxygen-15-labelled water. Left ventricular function, MGU, and MBF were re-assessed after one year, immediately prior to CABG. At baseline, dysfunctional myocardium displayed a reduction in MGU, hyperaemic MBF, and coronary vasodilator reserve (CVR) compared to normally functioning muscle. In the year preceding CABG, the overall wall motion score index increased (2.09 +/- 0.65 vs. 2.3 +/- 0.7, p=0.0001) and the LV ejection fraction decreased (30.6 +/- 11.1% vs. 27.3 +/- 11.5%, p
Original languageEnglish
Pages (from-to)500-507
Number of pages8
JournalEuropean Heart Journal
Volume25
DOIs
Publication statusPublished - 1 Mar 2004

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