The Multi-Center Randomized Controlled Trial (RCT) Published by the Journal of the American Medical Association (JAMA) on the Effect of Periodontal Therapy on Glycated Hemoglobin (HbA1c) Has Fundamental Problems

Wenche S Borgnakke; Iain L C Chapple; Robert J Genco; Gary Armitage; P Mark Bartold; Francesco D'Aiuto; Paul I Eke; William V Giannobile; Thomas Kocher; Kenneth S Kornman; Niklaus P Lang; Phoebus N Madianos; Shinya Murakami; Fusanori Nishimura; Steven Offenbacher; Philip M Preshaw; Amin Ur Rahman; Mariano Sanz; Jørgen Slots; Maurizio S Tonetti; Thomas E Van Dyke

doi:10.1016/j.jebdp.2014.04.017

The Multi-Center Randomized Controlled Trial (RCT) Published by the Journal of the American Medical Association (JAMA) on the Effect of Periodontal Therapy on Glycated Hemoglobin (HbA1c) Has Fundamental Problems

Wenche S Borgnakke
, Iain L C Chapple
, Robert J Genco
, Gary Armitage
, P Mark Bartold
, Francesco D'Aiuto
, Paul I Eke
, William V Giannobile
, Thomas Kocher
, Kenneth S Kornman
, Niklaus P Lang
, Phoebus N Madianos
, Shinya Murakami
, Fusanori Nishimura
, Steven Offenbacher
, Philip M Preshaw
, Amin Ur Rahman
, Mariano Sanz
, Jørgen Slots
, Maurizio S Tonetti

Thomas E Van Dyke

Dentistry

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

481 Downloads (Pure)

Abstract

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial. Engebretson SP, Hyman LG, Michalowicz BS, Schoenfeld ER, Gelato MC, Hou W, et al (16 authors). JAMA 2013;310(23):2523-32.

REVIEWERS: Wenche S. Borgnakke, Iain L. C. Chapple, Robert J. Genco, Gary Armitage, P. Mark Bartold, Francesco D'Aiuto, Paul I. Eke, William V. Giannobile, Thomas Kocher, Kenneth S. Kornman, Niklaus P. Lang, Phoebus N. Madianos, Shinya Murakami, Fusanori Nishimura, Steven Offenbacher, Philip M. Preshaw, Amin ur Rahman, Mariano Sanz, Jørgen Slots, Maurizio S. Tonetti, Thomas E. Van Dyke

PURPOSE/QUESTION: Does non-surgical periodontal treatment reduce levels of HbA1c in persons with type 2 diabetes and moderate to advanced chronic periodontitis?

SOURCE OF FUNDING: US Government - National Institute of Dental and Craniofacial Research, National Institutes of Health: Cooperative agreements ($15.4M): 1) UO1 DE018902 (Dr. Engebretson: $11.1M) and 2) U01 DE018886 (Dr. Hyman: $4.3M) TYPE OF STUDY/DESIGN: Multi-center RCT.

TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT00997178.

LEVEL OF EVIDENCE: Level 2: Limited-quality, patient-oriented evidence

STRENGTH OF RECOMMENDATION GRADE: Not applicable.

Original language	English
Pages (from-to)	127-32
Number of pages	6
Journal	Journal of Evidence Based Dental Practice
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/j.jebdp.2014.04.017
Publication status	Published - Sept 2014

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Borgnakke, W. S., Chapple, I. L. C., Genco, R. J., Armitage, G., Bartold, P. M., D'Aiuto, F., Eke, P. I., Giannobile, W. V., Kocher, T., Kornman, K. S., Lang, N. P., Madianos, P. N., Murakami, S., Nishimura, F., Offenbacher, S., Preshaw, P. M., Rahman, A. U., Sanz, M., Slots, J., ... Van Dyke, T. E. (2014). The Multi-Center Randomized Controlled Trial (RCT) Published by the Journal of the American Medical Association (JAMA) on the Effect of Periodontal Therapy on Glycated Hemoglobin (HbA1c) Has Fundamental Problems. Journal of Evidence Based Dental Practice, 14(3), 127-32. https://doi.org/10.1016/j.jebdp.2014.04.017

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abstract = "ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial. Engebretson SP, Hyman LG, Michalowicz BS, Schoenfeld ER, Gelato MC, Hou W, et al (16 authors). JAMA 2013;310(23):2523-32.REVIEWERS: Wenche S. Borgnakke, Iain L. C. Chapple, Robert J. Genco, Gary Armitage, P. Mark Bartold, Francesco D'Aiuto, Paul I. Eke, William V. Giannobile, Thomas Kocher, Kenneth S. Kornman, Niklaus P. Lang, Phoebus N. Madianos, Shinya Murakami, Fusanori Nishimura, Steven Offenbacher, Philip M. Preshaw, Amin ur Rahman, Mariano Sanz, J{\o}rgen Slots, Maurizio S. Tonetti, Thomas E. Van DykePURPOSE/QUESTION: Does non-surgical periodontal treatment reduce levels of HbA1c in persons with type 2 diabetes and moderate to advanced chronic periodontitis?SOURCE OF FUNDING: US Government - National Institute of Dental and Craniofacial Research, National Institutes of Health: Cooperative agreements (\$15.4M): 1) UO1 DE018902 (Dr. Engebretson: \$11.1M) and 2) U01 DE018886 (Dr. Hyman: \$4.3M) TYPE OF STUDY/DESIGN: Multi-center RCT.TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT00997178.LEVEL OF EVIDENCE: Level 2: Limited-quality, patient-oriented evidenceSTRENGTH OF RECOMMENDATION GRADE: Not applicable.",

author = "Borgnakke, \{Wenche S\} and Chapple, \{Iain L C\} and Genco, \{Robert J\} and Gary Armitage and Bartold, \{P Mark\} and Francesco D'Aiuto and Eke, \{Paul I\} and Giannobile, \{William V\} and Thomas Kocher and Kornman, \{Kenneth S\} and Lang, \{Niklaus P\} and Madianos, \{Phoebus N\} and Shinya Murakami and Fusanori Nishimura and Steven Offenbacher and Preshaw, \{Philip M\} and Rahman, \{Amin Ur\} and Mariano Sanz and J{\o}rgen Slots and Tonetti, \{Maurizio S\} and \{Van Dyke\}, \{Thomas E\}",

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Borgnakke, WS, Chapple, ILC, Genco, RJ, Armitage, G, Bartold, PM, D'Aiuto, F, Eke, PI, Giannobile, WV, Kocher, T, Kornman, KS, Lang, NP, Madianos, PN, Murakami, S, Nishimura, F, Offenbacher, S, Preshaw, PM, Rahman, AU, Sanz, M, Slots, J, Tonetti, MS & Van Dyke, TE 2014, 'The Multi-Center Randomized Controlled Trial (RCT) Published by the Journal of the American Medical Association (JAMA) on the Effect of Periodontal Therapy on Glycated Hemoglobin (HbA1c) Has Fundamental Problems', Journal of Evidence Based Dental Practice, vol. 14, no. 3, pp. 127-32. https://doi.org/10.1016/j.jebdp.2014.04.017

The Multi-Center Randomized Controlled Trial (RCT) Published by the Journal of the American Medical Association (JAMA) on the Effect of Periodontal Therapy on Glycated Hemoglobin (HbA1c) Has Fundamental Problems. / Borgnakke, Wenche S; Chapple, Iain L C; Genco, Robert J et al.
In: Journal of Evidence Based Dental Practice, Vol. 14, No. 3, 09.2014, p. 127-32.

Research output: Contribution to journal › Article › peer-review

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T1 - The Multi-Center Randomized Controlled Trial (RCT) Published by the Journal of the American Medical Association (JAMA) on the Effect of Periodontal Therapy on Glycated Hemoglobin (HbA1c) Has Fundamental Problems

AU - Borgnakke, Wenche S

AU - Chapple, Iain L C

AU - Genco, Robert J

AU - Armitage, Gary

AU - Bartold, P Mark

AU - D'Aiuto, Francesco

AU - Eke, Paul I

AU - Giannobile, William V

AU - Kocher, Thomas

AU - Kornman, Kenneth S

AU - Lang, Niklaus P

AU - Madianos, Phoebus N

AU - Murakami, Shinya

AU - Nishimura, Fusanori

AU - Offenbacher, Steven

AU - Preshaw, Philip M

AU - Rahman, Amin Ur

AU - Sanz, Mariano

AU - Slots, Jørgen

AU - Tonetti, Maurizio S

AU - Van Dyke, Thomas E

PY - 2014/9

Y1 - 2014/9

N2 - ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial. Engebretson SP, Hyman LG, Michalowicz BS, Schoenfeld ER, Gelato MC, Hou W, et al (16 authors). JAMA 2013;310(23):2523-32.REVIEWERS: Wenche S. Borgnakke, Iain L. C. Chapple, Robert J. Genco, Gary Armitage, P. Mark Bartold, Francesco D'Aiuto, Paul I. Eke, William V. Giannobile, Thomas Kocher, Kenneth S. Kornman, Niklaus P. Lang, Phoebus N. Madianos, Shinya Murakami, Fusanori Nishimura, Steven Offenbacher, Philip M. Preshaw, Amin ur Rahman, Mariano Sanz, Jørgen Slots, Maurizio S. Tonetti, Thomas E. Van DykePURPOSE/QUESTION: Does non-surgical periodontal treatment reduce levels of HbA1c in persons with type 2 diabetes and moderate to advanced chronic periodontitis?SOURCE OF FUNDING: US Government - National Institute of Dental and Craniofacial Research, National Institutes of Health: Cooperative agreements ($15.4M): 1) UO1 DE018902 (Dr. Engebretson: $11.1M) and 2) U01 DE018886 (Dr. Hyman: $4.3M) TYPE OF STUDY/DESIGN: Multi-center RCT.TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT00997178.LEVEL OF EVIDENCE: Level 2: Limited-quality, patient-oriented evidenceSTRENGTH OF RECOMMENDATION GRADE: Not applicable.

AB - ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial. Engebretson SP, Hyman LG, Michalowicz BS, Schoenfeld ER, Gelato MC, Hou W, et al (16 authors). JAMA 2013;310(23):2523-32.REVIEWERS: Wenche S. Borgnakke, Iain L. C. Chapple, Robert J. Genco, Gary Armitage, P. Mark Bartold, Francesco D'Aiuto, Paul I. Eke, William V. Giannobile, Thomas Kocher, Kenneth S. Kornman, Niklaus P. Lang, Phoebus N. Madianos, Shinya Murakami, Fusanori Nishimura, Steven Offenbacher, Philip M. Preshaw, Amin ur Rahman, Mariano Sanz, Jørgen Slots, Maurizio S. Tonetti, Thomas E. Van DykePURPOSE/QUESTION: Does non-surgical periodontal treatment reduce levels of HbA1c in persons with type 2 diabetes and moderate to advanced chronic periodontitis?SOURCE OF FUNDING: US Government - National Institute of Dental and Craniofacial Research, National Institutes of Health: Cooperative agreements ($15.4M): 1) UO1 DE018902 (Dr. Engebretson: $11.1M) and 2) U01 DE018886 (Dr. Hyman: $4.3M) TYPE OF STUDY/DESIGN: Multi-center RCT.TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT00997178.LEVEL OF EVIDENCE: Level 2: Limited-quality, patient-oriented evidenceSTRENGTH OF RECOMMENDATION GRADE: Not applicable.

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Borgnakke WS, Chapple ILC, Genco RJ, Armitage G, Bartold PM, D'Aiuto F et al. The Multi-Center Randomized Controlled Trial (RCT) Published by the Journal of the American Medical Association (JAMA) on the Effect of Periodontal Therapy on Glycated Hemoglobin (HbA1c) Has Fundamental Problems. Journal of Evidence Based Dental Practice. 2014 Sept;14(3):127-32. doi: 10.1016/j.jebdp.2014.04.017