The mucormycete-host interface

Ashraf S Ibrahim, Kerstin Voelz

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)
135 Downloads (Pure)

Abstract

Mucormycosis is a fungal infection with fulminant angioinvasion leading to high morbidity and mortality in susceptible individuals. The major predisposing conditions are uncontrolled diabetes, neutropenia, malignancies, receipt of a transplant and traumatic injury [1]. Over the past decade, mucormycosis has become an emerging fungal infection due to the increase in patient groups presenting with these pre-disposing conditions and our medical advances in diagnosing the infection [2-4]. Yet, we currently lack clinical interventions to treat mucormycosis effectively. This in turn is due to a lack of understanding of mucormycosis pathogenesis.

Here, we discuss our current understanding of selected aspects of interactions at the mucormycete-host interface. We will highlight open questions that might guide future research directions for investigations into the pathogenesis of mucormycosis and potential innovative therapeutic approaches.
Original languageEnglish
Pages (from-to)40-45
JournalCurrent Opinion in Microbiology
Volume40
Early online date4 Nov 2017
DOIs
Publication statusPublished - Dec 2017

Keywords

  • fungal
  • iron
  • Mucormycosis
  • host-pathogen interaction
  • immunity
  • endothelial cells
  • macrophage
  • neutrophil
  • Rhizopus
  • Mucor
  • granuloma

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