TY - JOUR
T1 - The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project design and methodologies
T2 - a dimensional approach to understanding neurobiological and genetic aetiology
AU - Knott, Rachael
AU - Johnson, Beth P.
AU - Tiego, Jeggan
AU - Mellahn, Olivia
AU - Finlay, Amy
AU - Kallady, Kathryn
AU - Kouspos, Maria
AU - Mohanakumar Sindhu, Vishnu Priya
AU - Hawi, Ziarih
AU - Arnatkeviciute, Aurina
AU - Chau, Tracey
AU - Maron, Dalia
AU - Mercieca, Emily Clare
AU - Furley, Kirsten
AU - Harris, Katrina
AU - Williams, Katrina
AU - Ure, Alexandra
AU - Fornito, Alex
AU - Gray, Kylie
AU - Coghill, David
AU - Nicholson, Ann
AU - Phung, Dinh
AU - Loth, Eva
AU - Mason, Luke
AU - Murphy, Declan
AU - Buitelaar, Jan
AU - Bellgrove, Mark A.
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Background: ASD and ADHD are prevalent neurodevelopmental disorders that frequently co-occur and have strong evidence for a degree of shared genetic aetiology. Behavioural and neurocognitive heterogeneity in ASD and ADHD has hampered attempts to map the underlying genetics and neurobiology, predict intervention response, and improve diagnostic accuracy. Moving away from categorical conceptualisations of psychopathology to a dimensional approach is anticipated to facilitate discovery of data-driven clusters and enhance our understanding of the neurobiological and genetic aetiology of these conditions. The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project is one of the first large-scale, family-based studies to take a truly transdiagnostic approach to ASD and ADHD. Using a comprehensive phenotyping protocol capturing dimensional traits central to ASD and ADHD, the MAGNET project aims to identify data-driven clusters across ADHD-ASD spectra using deep phenotyping of symptoms and behaviours; investigate the degree of familiality for different dimensional ASD-ADHD phenotypes and clusters; and map the neurocognitive, brain imaging, and genetic correlates of these data-driven symptom-based clusters. Methods: The MAGNET project will recruit 1,200 families with children who are either typically developing, or who display elevated ASD, ADHD, or ASD-ADHD traits, in addition to affected and unaffected biological siblings of probands, and parents. All children will be comprehensively phenotyped for behavioural symptoms, comorbidities, neurocognitive and neuroimaging traits and genetics. Conclusion: The MAGNET project will be the first large-scale family study to take a transdiagnostic approach to ASD-ADHD, utilising deep phenotyping across behavioural, neurocognitive, brain imaging and genetic measures.
AB - Background: ASD and ADHD are prevalent neurodevelopmental disorders that frequently co-occur and have strong evidence for a degree of shared genetic aetiology. Behavioural and neurocognitive heterogeneity in ASD and ADHD has hampered attempts to map the underlying genetics and neurobiology, predict intervention response, and improve diagnostic accuracy. Moving away from categorical conceptualisations of psychopathology to a dimensional approach is anticipated to facilitate discovery of data-driven clusters and enhance our understanding of the neurobiological and genetic aetiology of these conditions. The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project is one of the first large-scale, family-based studies to take a truly transdiagnostic approach to ASD and ADHD. Using a comprehensive phenotyping protocol capturing dimensional traits central to ASD and ADHD, the MAGNET project aims to identify data-driven clusters across ADHD-ASD spectra using deep phenotyping of symptoms and behaviours; investigate the degree of familiality for different dimensional ASD-ADHD phenotypes and clusters; and map the neurocognitive, brain imaging, and genetic correlates of these data-driven symptom-based clusters. Methods: The MAGNET project will recruit 1,200 families with children who are either typically developing, or who display elevated ASD, ADHD, or ASD-ADHD traits, in addition to affected and unaffected biological siblings of probands, and parents. All children will be comprehensively phenotyped for behavioural symptoms, comorbidities, neurocognitive and neuroimaging traits and genetics. Conclusion: The MAGNET project will be the first large-scale family study to take a transdiagnostic approach to ASD-ADHD, utilising deep phenotyping across behavioural, neurocognitive, brain imaging and genetic measures.
KW - ADHD
KW - ASD
KW - Cognition
KW - Eye-tracking
KW - Genetics
KW - HiTOP
KW - Neuroimaging
KW - RDoC
UR - http://www.scopus.com/inward/record.url?scp=85112654556&partnerID=8YFLogxK
U2 - 10.1186/s13229-021-00457-3
DO - 10.1186/s13229-021-00457-3
M3 - Article
C2 - 34353377
AN - SCOPUS:85112654556
SN - 2040-2392
VL - 12
JO - Molecular Autism
JF - Molecular Autism
IS - 1
M1 - 55
ER -
