TY - JOUR
T1 - The MHC class ll region, CTLA-4 gene and ophthalmopathy in patients with Graves' disease
AU - Allahabadia, Amit
AU - King, Joanne
AU - Nithyananthan, R
AU - Gibson, Sarah
AU - Reuser, Tristan
AU - Dodson, Paul
AU - Franklyn, Jayne
AU - Gough, Stephen
PY - 2001/9/22
Y1 - 2001/9/22
N2 - Up to half of patients with Graves' hyperthyroidism have signs of thyroid associated ophthalmopathy, but the factors that cause this disorder are unknown. We investigated two major genetic susceptibility loci for Graves' disease in ophthalmopathy; the MHC class II region and the cytotoxic T lymphocyte antigen-4 (CTLA4) gene. Allelic frequencies of these genes in patients with Graves' disease who did and did not have concurrent thyroid-associated ophthalmopathy did not differ, and are, therefore, unlikely to contribute to its development.
AB - Up to half of patients with Graves' hyperthyroidism have signs of thyroid associated ophthalmopathy, but the factors that cause this disorder are unknown. We investigated two major genetic susceptibility loci for Graves' disease in ophthalmopathy; the MHC class II region and the cytotoxic T lymphocyte antigen-4 (CTLA4) gene. Allelic frequencies of these genes in patients with Graves' disease who did and did not have concurrent thyroid-associated ophthalmopathy did not differ, and are, therefore, unlikely to contribute to its development.
UR - http://www.scopus.com/inward/record.url?scp=0035934489&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(01)06125-6
DO - 10.1016/S0140-6736(01)06125-6
M3 - Article
C2 - 11583755
SN - 1474-547X
VL - 358
SP - 984
EP - 985
JO - Lancet
JF - Lancet
IS - 9286
ER -