The methionine synthase polymorphism D919G alters susceptibility to primary nervous system lymphoma

M Linnebank; S Schmidt; H Kolsch; A Linnebank; Reinhard Heun; IGH Schmidt-Wolf; A Glasmacher; K Fliessbach; T Klockgether; U Schlegel; H Pels

doi:10.1038/sj.bjc.6601777

The methionine synthase polymorphism D919G alters susceptibility to primary nervous system lymphoma

M Linnebank, S Schmidt, H Kolsch, A Linnebank, Reinhard Heun, IGH Schmidt-Wolf, A Glasmacher, K Fliessbach, T Klockgether, U Schlegel, H Pels

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Abstract

Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the methionine synthase c.2756A>G (D919G) missense polymorphism among the patients (0.16 vs 0.42; odds ratio 0.26, CI(95%): 0.09-0.74; P=0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homocysteine and folate metabolism in lymphoma tumorigenesis.

Original language	English
Pages (from-to)	1969-71
Number of pages	3
Journal	British Journal of Cancer
Volume	90
DOIs	https://doi.org/10.1038/sj.bjc.6601777
Publication status	Published - 6 Apr 2004

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title = "The methionine synthase polymorphism D919G alters susceptibility to primary nervous system lymphoma",

abstract = "Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the methionine synthase c.2756A>G (D919G) missense polymorphism among the patients (0.16 vs 0.42; odds ratio 0.26, CI(95%): 0.09-0.74; P=0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homocysteine and folate metabolism in lymphoma tumorigenesis.",

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T1 - The methionine synthase polymorphism D919G alters susceptibility to primary nervous system lymphoma

AU - Linnebank, M

AU - Schmidt, S

AU - Kolsch, H

AU - Linnebank, A

AU - Heun, Reinhard

AU - Schmidt-Wolf, IGH

AU - Glasmacher, A

AU - Fliessbach, K

AU - Klockgether, T

AU - Schlegel, U

AU - Pels, H

PY - 2004/4/6

Y1 - 2004/4/6

N2 - Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the methionine synthase c.2756A>G (D919G) missense polymorphism among the patients (0.16 vs 0.42; odds ratio 0.26, CI(95%): 0.09-0.74; P=0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homocysteine and folate metabolism in lymphoma tumorigenesis.

AB - Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the methionine synthase c.2756A>G (D919G) missense polymorphism among the patients (0.16 vs 0.42; odds ratio 0.26, CI(95%): 0.09-0.74; P=0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homocysteine and folate metabolism in lymphoma tumorigenesis.

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DO - 10.1038/sj.bjc.6601777

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VL - 90

SP - 1969

EP - 1971

JO - British Journal of Cancer

JF - British Journal of Cancer

ER -

The methionine synthase polymorphism D919G alters susceptibility to primary nervous system lymphoma

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