The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice

Amy J Naylor; Eman Azzam; Stuart Smith; Adam Croft; Callum Poyser; Jeremy S Duffield; David L Huso; Steffen Gay; Caroline Ospelt; Mark Cooper; Clare Isacke; Simon R Goodyear; Michael J Rogers; Christopher D Buckley

doi:10.1002/art.34556

The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice

Amy J Naylor
, Eman Azzam
, Stuart Smith
, Adam Croft
, Callum Poyser
, Jeremy S Duffield
, David L Huso
, Steffen Gay
, Caroline Ospelt
, Mark Cooper
, Clare Isacke
, Simon R Goodyear
, Michael J Rogers
, Christopher D Buckley

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

449 Downloads (Pure)

Abstract

CD248 (tumor endothelial marker 1/endosialin) is found on stromal cells and is highly expressed during malignancy and inflammation. Studies have shown a reduction in inflammatory arthritis in CD248-knockout (CD248(-/-) ) mice. The aim of the present study was to investigate the functional effect of genetic deletion of CD248 on bone mass.

Original language	English
Pages (from-to)	3334-3343
Number of pages	10
Journal	Arthritis & Rheumatism
Volume	64
Issue number	10
DOIs	https://doi.org/10.1002/art.34556
Publication status	Published - 27 Sept 2012

Access to Document

10.1002/art.34556

Naylor et al emss-60643Accepted author manuscript, 1.15 MBLicence: Unspecified

Cite this

Naylor, A. J., Azzam, E., Smith, S., Croft, A., Poyser, C., Duffield, J. S., Huso, D. L., Gay, S., Ospelt, C., Cooper, M., Isacke, C., Goodyear, S. R., Rogers, M. J., & Buckley, C. D. (2012). The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice. Arthritis & Rheumatism, 64(10), 3334-3343. https://doi.org/10.1002/art.34556

@article{22eb6befd85d49f5a96feddd0bb74fd6,

title = "The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice",

abstract = "CD248 (tumor endothelial marker 1/endosialin) is found on stromal cells and is highly expressed during malignancy and inflammation. Studies have shown a reduction in inflammatory arthritis in CD248-knockout (CD248(-/-) ) mice. The aim of the present study was to investigate the functional effect of genetic deletion of CD248 on bone mass.",

author = "Naylor, \{Amy J\} and Eman Azzam and Stuart Smith and Adam Croft and Callum Poyser and Duffield, \{Jeremy S\} and Huso, \{David L\} and Steffen Gay and Caroline Ospelt and Mark Cooper and Clare Isacke and Goodyear, \{Simon R\} and Rogers, \{Michael J\} and Buckley, \{Christopher D\}",

note = "Copyright {\textcopyright} 2012 by the American College of Rheumatology.",

year = "2012",

month = sep,

day = "27",

doi = "10.1002/art.34556",

language = "English",

volume = "64",

pages = "3334--3343",

journal = "Arthritis \& Rheumatism",

issn = "1529-0131",

publisher = "Wiley",

number = "10",

}

TY - JOUR

T1 - The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice

AU - Naylor, Amy J

AU - Azzam, Eman

AU - Smith, Stuart

AU - Croft, Adam

AU - Poyser, Callum

AU - Duffield, Jeremy S

AU - Huso, David L

AU - Gay, Steffen

AU - Ospelt, Caroline

AU - Cooper, Mark

AU - Isacke, Clare

AU - Goodyear, Simon R

AU - Rogers, Michael J

AU - Buckley, Christopher D

PY - 2012/9/27

Y1 - 2012/9/27

N2 - CD248 (tumor endothelial marker 1/endosialin) is found on stromal cells and is highly expressed during malignancy and inflammation. Studies have shown a reduction in inflammatory arthritis in CD248-knockout (CD248(-/-) ) mice. The aim of the present study was to investigate the functional effect of genetic deletion of CD248 on bone mass.

AB - CD248 (tumor endothelial marker 1/endosialin) is found on stromal cells and is highly expressed during malignancy and inflammation. Studies have shown a reduction in inflammatory arthritis in CD248-knockout (CD248(-/-) ) mice. The aim of the present study was to investigate the functional effect of genetic deletion of CD248 on bone mass.

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209224/

U2 - 10.1002/art.34556

DO - 10.1002/art.34556

M3 - Article

C2 - 22674221

SN - 1529-0131

VL - 64

SP - 3334

EP - 3343

JO - Arthritis & Rheumatism

JF - Arthritis & Rheumatism

IS - 10

ER -

The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice

Abstract

Access to Document

Fingerprint

Cite this