The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice

Amy J Naylor, Eman Azzam, Stuart Smith, Adam Croft, Callum Poyser, Jeremy S Duffield, David L Huso, Steffen Gay, Caroline Ospelt, Mark Cooper, Clare Isacke, Simon R Goodyear, Michael J Rogers, Christopher D Buckley

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)
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Abstract

CD248 (tumor endothelial marker 1/endosialin) is found on stromal cells and is highly expressed during malignancy and inflammation. Studies have shown a reduction in inflammatory arthritis in CD248-knockout (CD248(-/-) ) mice. The aim of the present study was to investigate the functional effect of genetic deletion of CD248 on bone mass.
Original languageEnglish
Pages (from-to)3334-3343
Number of pages10
JournalArthritis & Rheumatism
Volume64
Issue number10
DOIs
Publication statusPublished - 27 Sep 2012

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