The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice

Amy J Naylor; Eman Azzam; Stuart Smith; Adam Croft; Callum Poyser; Jeremy S Duffield; David L Huso; Steffen Gay; Caroline Ospelt; Mark Cooper; Clare Isacke; Simon R Goodyear; Michael J Rogers; Christopher D Buckley

doi:10.1002/art.34556

The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice

Amy J Naylor, Eman Azzam, Stuart Smith, Adam Croft, Callum Poyser, Jeremy S Duffield, David L Huso, Steffen Gay, Caroline Ospelt, Mark Cooper, Clare Isacke, Simon R Goodyear, Michael J Rogers, Christopher D Buckley

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Abstract

CD248 (tumor endothelial marker 1/endosialin) is found on stromal cells and is highly expressed during malignancy and inflammation. Studies have shown a reduction in inflammatory arthritis in CD248-knockout (CD248(-/-) ) mice. The aim of the present study was to investigate the functional effect of genetic deletion of CD248 on bone mass.

Original language	English
Pages (from-to)	3334-3343
Number of pages	10
Journal	Arthritis & Rheumatism
Volume	64
Issue number	10
DOIs	https://doi.org/10.1002/art.34556
Publication status	Published - 27 Sept 2012

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Naylor et al emss-60643Accepted author manuscript, 1.15 MBLicence: Unspecified

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Naylor, A. J., Azzam, E., Smith, S., Croft, A., Poyser, C., Duffield, J. S., Huso, D. L., Gay, S., Ospelt, C., Cooper, M., Isacke, C., Goodyear, S. R., Rogers, M. J., & Buckley, C. D. (2012). The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice. Arthritis & Rheumatism, 64(10), 3334-3343. https://doi.org/10.1002/art.34556

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abstract = "CD248 (tumor endothelial marker 1/endosialin) is found on stromal cells and is highly expressed during malignancy and inflammation. Studies have shown a reduction in inflammatory arthritis in CD248-knockout (CD248(-/-) ) mice. The aim of the present study was to investigate the functional effect of genetic deletion of CD248 on bone mass.",

author = "Naylor, {Amy J} and Eman Azzam and Stuart Smith and Adam Croft and Callum Poyser and Duffield, {Jeremy S} and Huso, {David L} and Steffen Gay and Caroline Ospelt and Mark Cooper and Clare Isacke and Goodyear, {Simon R} and Rogers, {Michael J} and Buckley, {Christopher D}",

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AU - Azzam, Eman

AU - Smith, Stuart

AU - Croft, Adam

AU - Poyser, Callum

AU - Duffield, Jeremy S

AU - Huso, David L

AU - Gay, Steffen

AU - Ospelt, Caroline

AU - Cooper, Mark

AU - Isacke, Clare

AU - Goodyear, Simon R

AU - Rogers, Michael J

AU - Buckley, Christopher D

PY - 2012/9/27

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N2 - CD248 (tumor endothelial marker 1/endosialin) is found on stromal cells and is highly expressed during malignancy and inflammation. Studies have shown a reduction in inflammatory arthritis in CD248-knockout (CD248(-/-) ) mice. The aim of the present study was to investigate the functional effect of genetic deletion of CD248 on bone mass.

AB - CD248 (tumor endothelial marker 1/endosialin) is found on stromal cells and is highly expressed during malignancy and inflammation. Studies have shown a reduction in inflammatory arthritis in CD248-knockout (CD248(-/-) ) mice. The aim of the present study was to investigate the functional effect of genetic deletion of CD248 on bone mass.

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209224/

U2 - 10.1002/art.34556

DO - 10.1002/art.34556

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EP - 3343

JO - Arthritis & Rheumatism

JF - Arthritis & Rheumatism

IS - 10

ER -

The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice

Abstract

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