The McKittrick-Wheelock Syndrome: A Case of Acute Renal Failure Due to Neoplastic Cholera

V Winstanley, Mark Little, C Wadsworth, P Cohen, N Martin

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8 Citations (Scopus)


The McKittrick-Wheelock syndrome is characterized by severe electrolyte and fluid depletion as a result of rectal tumor hypersecretion. Typically, a metabolic acidosis ensues. We report the case of a 58-year-old man who presented with a mixed metabolic acidosis and alkalosis. He was hyponatremic, hypokalemic, and hypochloremic, with acute renal failure on blood testing. Following fluid resuscitation, a predominant alkalemia was observed. The patient was found to be passing 1.5 L of mucous per rectum per day, containing high concentrations of sodium and potassium, similar to that observed in cholera stool. A large rectal villous adenoma was discovered on sigmoidoscopy, and definitive management was achieved by removal of the tumor. This case provides a demonstration of the ranging metabolic disturbance associated with secretory diarrhea. Other endogenous and infective causes are discussed, and mechanisms compared with the case described.
Original languageEnglish
Pages (from-to)469-473
Number of pages5
JournalRenal Failure
Issue number4
Publication statusPublished - 1 May 2008


  • cholera
  • villous adenoma
  • metabolic alkalosis
  • delta anion gap
  • McKittrick-Wheelock syndrome


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