The LUCA device: a multi-modal platform combining diffuse optics and ultrasound imaging for thyroid cancer screening

Lorenzo Cortese; Giuseppe Lo Presti; Marta Zanoletti; Gloria Aranda; Mauro Buttafava; Davide Contini; Alberto Dalla Mora; Hamid Dehghani; Laura Di Sieno; Sixte de Fraguier; Felicia A Hanzu; Mireia Mora Porta; An Nguyen-Dinh; Marco Renna; Bogdan Rosinski; Mattia Squarcia; Alberto Tosi; Udo M Weigel; Stanislaw Wojtkiewicz; Turgut Durduran

doi:10.1364/BOE.416561

The LUCA device: a multi-modal platform combining diffuse optics and ultrasound imaging for thyroid cancer screening

Lorenzo Cortese, Giuseppe Lo Presti, Marta Zanoletti, Gloria Aranda, Mauro Buttafava, Davide Contini, Alberto Dalla Mora, Hamid Dehghani, Laura Di Sieno, Sixte de Fraguier, Felicia A Hanzu, Mireia Mora Porta, An Nguyen-Dinh, Marco Renna, Bogdan Rosinski, Mattia Squarcia, Alberto Tosi, Udo M Weigel, Stanislaw Wojtkiewicz, Turgut Durduran

Computer Science

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Abstract

We present the LUCA device, a multi-modal platform combining eight-wavelength near infrared time resolved spectroscopy, sixteen-channel diffuse correlation spectroscopy and a clinical ultrasound in a single device. By simultaneously measuring the tissue hemodynamics and performing ultrasound imaging, this platform aims to tackle the low specificity and sensitivity of the current thyroid cancer diagnosis techniques, improving the screening of thyroid nodules. Here, we show a detailed description of the device, components and modules. Furthermore, we show the device tests performed through well established protocols for phantom validation, and the performance assessment for in vivo. The characterization tests demonstrate that LUCA device is capable of performing high quality measurements, with a precision in determining in vivo tissue optical and dynamic properties of better than 3%, and a reproducibility of better than 10% after ultrasound-guided probe repositioning, even with low photon count-rates, making it suitable for a wide variety of clinical applications.

Original language	English
Pages (from-to)	3392-3409
Number of pages	18
Journal	Biomedical Optics Express
Volume	12
Issue number	6
Early online date	14 May 2021
DOIs	https://doi.org/10.1364/BOE.416561
Publication status	Published - 1 Jun 2021

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CorteseL2021LUCA
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Cortese, L., Lo Presti, G., Zanoletti, M., Aranda, G., Buttafava, M., Contini, D., Dalla Mora, A., Dehghani, H., Di Sieno, L., de Fraguier, S., Hanzu, F. A., Mora Porta, M., Nguyen-Dinh, A., Renna, M., Rosinski, B., Squarcia, M., Tosi, A., Weigel, U. M., Wojtkiewicz, S., & Durduran, T. (2021). The LUCA device: a multi-modal platform combining diffuse optics and ultrasound imaging for thyroid cancer screening. Biomedical Optics Express, 12(6), 3392-3409. Advance online publication. https://doi.org/10.1364/BOE.416561

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abstract = "We present the LUCA device, a multi-modal platform combining eight-wavelength near infrared time resolved spectroscopy, sixteen-channel diffuse correlation spectroscopy and a clinical ultrasound in a single device. By simultaneously measuring the tissue hemodynamics and performing ultrasound imaging, this platform aims to tackle the low specificity and sensitivity of the current thyroid cancer diagnosis techniques, improving the screening of thyroid nodules. Here, we show a detailed description of the device, components and modules. Furthermore, we show the device tests performed through well established protocols for phantom validation, and the performance assessment for in vivo. The characterization tests demonstrate that LUCA device is capable of performing high quality measurements, with a precision in determining in vivo tissue optical and dynamic properties of better than 3%, and a reproducibility of better than 10% after ultrasound-guided probe repositioning, even with low photon count-rates, making it suitable for a wide variety of clinical applications.",

author = "Lorenzo Cortese and {Lo Presti}, Giuseppe and Marta Zanoletti and Gloria Aranda and Mauro Buttafava and Davide Contini and {Dalla Mora}, Alberto and Hamid Dehghani and {Di Sieno}, Laura and {de Fraguier}, Sixte and Hanzu, {Felicia A} and {Mora Porta}, Mireia and An Nguyen-Dinh and Marco Renna and Bogdan Rosinski and Mattia Squarcia and Alberto Tosi and Weigel, {Udo M} and Stanislaw Wojtkiewicz and Turgut Durduran",

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Cortese, L, Lo Presti, G, Zanoletti, M, Aranda, G, Buttafava, M, Contini, D, Dalla Mora, A, Dehghani, H, Di Sieno, L, de Fraguier, S, Hanzu, FA, Mora Porta, M, Nguyen-Dinh, A, Renna, M, Rosinski, B, Squarcia, M, Tosi, A, Weigel, UM, Wojtkiewicz, S & Durduran, T 2021, 'The LUCA device: a multi-modal platform combining diffuse optics and ultrasound imaging for thyroid cancer screening', Biomedical Optics Express, vol. 12, no. 6, pp. 3392-3409. https://doi.org/10.1364/BOE.416561

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AU - Cortese, Lorenzo

AU - Lo Presti, Giuseppe

AU - Zanoletti, Marta

AU - Aranda, Gloria

AU - Buttafava, Mauro

AU - Contini, Davide

AU - Dalla Mora, Alberto

AU - Dehghani, Hamid

AU - Di Sieno, Laura

AU - de Fraguier, Sixte

AU - Hanzu, Felicia A

AU - Mora Porta, Mireia

AU - Nguyen-Dinh, An

AU - Renna, Marco

AU - Rosinski, Bogdan

AU - Squarcia, Mattia

AU - Tosi, Alberto

AU - Weigel, Udo M

AU - Wojtkiewicz, Stanislaw

AU - Durduran, Turgut

PY - 2021/6/1

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AB - We present the LUCA device, a multi-modal platform combining eight-wavelength near infrared time resolved spectroscopy, sixteen-channel diffuse correlation spectroscopy and a clinical ultrasound in a single device. By simultaneously measuring the tissue hemodynamics and performing ultrasound imaging, this platform aims to tackle the low specificity and sensitivity of the current thyroid cancer diagnosis techniques, improving the screening of thyroid nodules. Here, we show a detailed description of the device, components and modules. Furthermore, we show the device tests performed through well established protocols for phantom validation, and the performance assessment for in vivo. The characterization tests demonstrate that LUCA device is capable of performing high quality measurements, with a precision in determining in vivo tissue optical and dynamic properties of better than 3%, and a reproducibility of better than 10% after ultrasound-guided probe repositioning, even with low photon count-rates, making it suitable for a wide variety of clinical applications.

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ER -

The LUCA device: a multi-modal platform combining diffuse optics and ultrasound imaging for thyroid cancer screening

Abstract

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