The lowdown on breakdown: Open questions in plant proteolysis

Nancy A Eckardt*, Tamar Avin-Wittenberg, Diane C Bassham, Poyu Chen, Qian Chen, Jun Fang, Pascal Genschik, Abi S Ghifari*, Angelica M Guercio, Daniel Gibbs, Maren Heese, R Paul Jarvis, Simon Michaeli, Monika W. Murcha, Sergey Mursalimov, Sandra Noir, Malathy Palayam, Bruno Peixoto, Pedro L Rodriguez, Andreas SchallerArp Schnittger, Giovanna Serino, Nitzan Shabek, Annick Stintzi, Frederica L Theodoulou, Suayib Üstün, Klaas J van Wijk, Ning Wei, Qi Xie, Feifei Yu, Hongtao Zhang

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Proteolysis, including post-translational proteolytic processing as well as protein degradation and amino acid recycling, is an essential component of the growth and development of living organisms. In this article, experts in plant proteolysis pose and discuss compelling open questions in their areas of research. Topics covered include the role of proteolysis in the cell cycle, DNA damage response, mitochondrial function, the generation of N-terminal signals (degrons) that mark many proteins for degradation (N-terminal acetylation, the Arg/N-degron pathway, and the chloroplast N-degron pathway), developmental and metabolic signaling (photomorphogenesis, abscisic acid and strigolactone signaling, sugar metabolism, and postharvest regulation), plant responses to environmental signals (endoplasmic-reticulum-associated degradation, chloroplast-associated degradation, drought tolerance, and the growth-defense trade-off), and the functional diversification of peptidases. We hope these thought-provoking discussions help to stimulate further research.

Original languageEnglish
Pages (from-to)2931-2975
Number of pages45
JournalThe Plant Cell
Volume36
Issue number9
Early online date9 Jul 2024
DOIs
Publication statusPublished - Sept 2024

Bibliographical note

© The Author(s) 2024. Published by Oxford University Press on behalf of American Society of Plant Biologists.

Keywords

  • Proteolysis
  • Plant Proteins/metabolism
  • Plants/metabolism
  • Signal Transduction
  • Protein Processing, Post-Translational

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