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The Lived Experience of Paranoia: Systematic Review of Qualitative Studies

  • Angela Muscettola*
  • , Giulia Drusiani
  • , Martina Desenzani
  • , Ludovico Belluardo
  • , Giovanni Antonio De Bellis
  • , Lisa Bortolotti
  • , Chiara Montemitro
  • , Andrea Escelsior
  • , Luigi Zerbinati
  • , Tommaso Toffanin
  • , Rosangela Caruso
  • , Maria Giulia Nanni
  • , Luigi Grassi
  • , Martino Belvederi Murri
  • *Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Background and Hypothesis
Paranoia is commonly conceptualised along a continuum ranging from transient suspiciousness and mistrust to fixed persecutory delusions. However, similar paranoid contents may differ in conviction, flexibility, self-reference, distress, functional impact, and embeddedness in broader changes of self, agency, and world-experience. We synthesised qualitative evidence on the subjective experience of paranoia, suspiciousness, mistrust, and persecutory threat.

Study Design
Following PRISMA and ENTREQ guidance, we searched PubMed/MEDLINE, Embase, PsycINFO, Scopus, EBSCOhost, and Ovid from inception to January 31, 2026. Thirty-six qualitative, experiential, or mixed-methods studies were included. Data were analysed using thematic synthesis informed by phenomenological principles. Studies were classified as core evidence when paranoia was central, or contextual evidence when paranoia-related material was embedded within broader phenomena.

Study Results
Three superordinate themes were generated: From interpersonal vigilance to a persecutory world; The threatened self: shame, vulnerability, trauma, and social injury; and Restoring meaning and safety: agency, coping, and altered reality. Paranoia emerged not only as a belief about threat, but as a situated transformation in the relation between self, others, and world. Lower-severity and non-clinical accounts were generally more localised, reflective, and negotiable. Clinical and higher-severity accounts were more pervasive, embodied, self-referential, and reality-defining, often intertwined with voices, external control, altered agency, spiritual meanings, or changes in reality-experience.

Conclusions
Paranoia is a multidimensional lived experience shaped by interpersonal threat, self-vulnerability, trauma, sociocultural context, coping, and meaning-making. Assessment should consider what paranoid beliefs mean, what they do for the person, and how they are shaped by biography, context, and lived experience.
Original languageEnglish
Article numbersgag027
JournalSchizophrenia Bulletin Open
Early online date26 Jul 2026
DOIs
Publication statusE-pub ahead of print - 26 Jul 2026

Keywords

  • paranoia
  • lived experience

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