Abstract
The killing kinetics of fleroxacin against four strains of Bacteroides fragilis were investigated. Viable counts were determined from 0 to 24 h after exposure to fleroxacin at multiples of the MIC. A one to three log reduction in viable count was observed after 2 h at 8 mg/l fleroxacin, and a more rapid rate of killing was seen at greater concentrations of the antimicrobial agent. An increase in cell length was observed at concentrations at and above the MIC from 2 h after exposure. The presence of a bacteriostatic concentration of chloramphenicol had negligible influence on viability but inhibited cell elongation.
| Original language | English |
|---|---|
| Pages (from-to) | 53-8 |
| Number of pages | 6 |
| Journal | Journal of Antimicrobial Chemotherapy |
| Volume | 23 |
| Issue number | 1 |
| Publication status | Published - Jan 1989 |
Keywords
- Anti-Bacterial Agents
- Bacteroides fragilis
- Cell Cycle
- Ciprofloxacin
- Drug Resistance, Microbial
- Fleroxacin
- Microbial Sensitivity Tests