The killing action of fleroxacin upon Bacteroides fragilis

D J Griggs, L J Piddock, R Wise

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10 Citations (Scopus)


The killing kinetics of fleroxacin against four strains of Bacteroides fragilis were investigated. Viable counts were determined from 0 to 24 h after exposure to fleroxacin at multiples of the MIC. A one to three log reduction in viable count was observed after 2 h at 8 mg/l fleroxacin, and a more rapid rate of killing was seen at greater concentrations of the antimicrobial agent. An increase in cell length was observed at concentrations at and above the MIC from 2 h after exposure. The presence of a bacteriostatic concentration of chloramphenicol had negligible influence on viability but inhibited cell elongation.
Original languageEnglish
Pages (from-to)53-8
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Issue number1
Publication statusPublished - Jan 1989


  • Anti-Bacterial Agents
  • Bacteroides fragilis
  • Cell Cycle
  • Ciprofloxacin
  • Drug Resistance, Microbial
  • Fleroxacin
  • Microbial Sensitivity Tests


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