The iron-induced ferredoxin FdxA of Campylobacter jejuni is involved in aerotolerance

AHM van Vliet, MLA Baillon, Charles Penn, JM Ketley

Research output: Contribution to journalArticle

38 Citations (Scopus)


A gene encoding a putative 2[4Fe-4S] ferredoxin (FdxA) was identified upstream of, and divergent to the peroxide stress defense gene ahpC of the microaerophilic pathogen Campylobacter jejuni. The transcription start site of fdxA was located 27 and 28 bp upstream of the fdxA start codon. Transcriptional fusions of the fdxA promoter to a lacZ reporter gene demonstrated that expression of fdxA is iron-induced, and thus oppositely regulated to the iron-repressed ahpC gene. Insertional mutagenesis of the fdxA gene did not affect microaerobic growth of C. jejuni, but significantly reduced aerotolerance of C. jejuni. The fdxA gene is the first reported iron-induced gene of C. jejuni, and encodes a novel component of its oxidative stress defense. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalFEMS Microbiology Letters
Issue number2
Publication statusPublished - 1 Mar 2001


  • aerotolerance
  • iron-sulfur protein
  • Campylobacter
  • oxidative stress


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