The International comparison of Systems of care and patient outcomes In minor Stroke and Tia (INSIST) study: a community-based cohort study

Christopher R Levi, Daniel Lasserson, Debbie Quain, Jose M Valderas, Helen M Dewey, Peter Barber, Peter Rothwell, Neil Spratt, Dominique A Cadilhac, Valery L Feigin, Hossein Zareie, Carlos Garcia-Esperon, Andrew Davey, Milton Sales, Nashwa Najib, Parker J Magin

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3 Citations (Scopus)
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Rationale: Rapid response by health-care systems for transient ischemic attack and minor stroke (TIA/mS) is recommended to maximize the impact of secondary prevention strategies. The applicability of this evidence to Australian non-hospital-based TIA/mS management is uncertain. Aims: Within an Australian community setting we seek to document processes of care, establish determinants of access to care, establish attack rates and determinants of recurrent vascular events and other clinical outcomes, establish the performance of ABC2-risk stratification, and compare the processes of care and outcomes to those in the UK and New Zealand for TIA/mS. Sample size estimates: Recruiting practices containing approximately 51 full-time-equivalent general practitioners to recruit 100 TIA/mS per year over a four-year study period will provide sufficient power for each of our outcomes. Methods and design: An inception cohort study of patients with possible TIA/mS recruited from 16 general practices in the Newcastle-Hunter Valley-Manning Valley region of Australia. Potential TIA/mS will be ascertained by multiple overlapping methods at general practices, after-hours collaborative, and hospital in-patient and outpatient services. Participants’ index and subsequent clinical events will be adjudicated as TIA/mS or mimics by an expert panel. Study outcomes: Process outcomes—whether the patient was referred for secondary care; time from event to first patient presentation to a health professional; time from event to specialist acute-access clinic appointment; time from event to brain and vascular imaging and relevant prescriptions. Clinical outcomes—recurrent stroke and major vascular events; and health-related quality of life. Discussion: Community management of TIA/mS will be informed by this study.

Original languageEnglish
Pages (from-to)186-190
Number of pages5
JournalInternational Journal of Stroke
Issue number2
Early online date4 Jan 2019
Publication statusPublished - 1 Feb 2019


  • Family practice
  • General Practice
  • Ischemic Attack
  • Transient
  • Delivery of Health Care
  • Health Care Quality
  • Access
  • and Evaluation
  • Health Behaviour


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