The influence of hydrostatic pressure on tissue engineered bone development

K H L Neßler; J R Henstock; A J El Haj; S L Waters; J P Whiteley; J M Osborne

doi:10.1016/j.jtbi.2015.12.020

The influence of hydrostatic pressure on tissue engineered bone development

K H L Neßler, J R Henstock, A J El Haj, S L Waters, J P Whiteley, J M Osborne

Chemical Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The hydrostatic pressure stimulation of an appropriately cell-seeded porous scaffold within a bioreactor is a promising method for engineering bone tissue external to the body. We propose a mathematical model, and employ a suite of candidate constitutive laws, to qualitatively describe the effect of applied hydrostatic pressure on the quantity of minerals deposited in such an experimental setup. By comparing data from numerical simulations with experimental observations under a number of stimulation protocols, we suggest that the response of bone cells to an applied pressure requires consideration of two components; (i) a component describing the cell memory of the applied stimulation, and (ii) a recovery component, capturing the time cells require to recover from high rates of mineralisation.

Original language	English
Pages (from-to)	149-159
Number of pages	11
Journal	Journal of Theoretical Biology
Volume	394
Early online date	18 Jan 2016
DOIs	https://doi.org/10.1016/j.jtbi.2015.12.020
Publication status	Published - 7 Apr 2016

Keywords

Bone Development
Calcification, Physiologic
Computer Simulation
Hydrostatic Pressure
Minerals/metabolism
Models, Biological
Tissue Engineering/methods

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10.1016/j.jtbi.2015.12.020

http://eprints.keele.ac.uk/1394/Licence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

Cite this

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title = "The influence of hydrostatic pressure on tissue engineered bone development",

abstract = "The hydrostatic pressure stimulation of an appropriately cell-seeded porous scaffold within a bioreactor is a promising method for engineering bone tissue external to the body. We propose a mathematical model, and employ a suite of candidate constitutive laws, to qualitatively describe the effect of applied hydrostatic pressure on the quantity of minerals deposited in such an experimental setup. By comparing data from numerical simulations with experimental observations under a number of stimulation protocols, we suggest that the response of bone cells to an applied pressure requires consideration of two components; (i) a component describing the cell memory of the applied stimulation, and (ii) a recovery component, capturing the time cells require to recover from high rates of mineralisation. ",

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doi = "10.1016/j.jtbi.2015.12.020",

language = "English",

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journal = "Journal of Theoretical Biology",

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T1 - The influence of hydrostatic pressure on tissue engineered bone development

AU - Neßler, K H L

AU - Henstock, J R

AU - El Haj, A J

AU - Waters, S L

AU - Whiteley, J P

AU - Osborne, J M

PY - 2016/4/7

Y1 - 2016/4/7

N2 - The hydrostatic pressure stimulation of an appropriately cell-seeded porous scaffold within a bioreactor is a promising method for engineering bone tissue external to the body. We propose a mathematical model, and employ a suite of candidate constitutive laws, to qualitatively describe the effect of applied hydrostatic pressure on the quantity of minerals deposited in such an experimental setup. By comparing data from numerical simulations with experimental observations under a number of stimulation protocols, we suggest that the response of bone cells to an applied pressure requires consideration of two components; (i) a component describing the cell memory of the applied stimulation, and (ii) a recovery component, capturing the time cells require to recover from high rates of mineralisation.

AB - The hydrostatic pressure stimulation of an appropriately cell-seeded porous scaffold within a bioreactor is a promising method for engineering bone tissue external to the body. We propose a mathematical model, and employ a suite of candidate constitutive laws, to qualitatively describe the effect of applied hydrostatic pressure on the quantity of minerals deposited in such an experimental setup. By comparing data from numerical simulations with experimental observations under a number of stimulation protocols, we suggest that the response of bone cells to an applied pressure requires consideration of two components; (i) a component describing the cell memory of the applied stimulation, and (ii) a recovery component, capturing the time cells require to recover from high rates of mineralisation.

KW - Bone Development

KW - Calcification, Physiologic

KW - Computer Simulation

KW - Hydrostatic Pressure

KW - Minerals/metabolism

KW - Models, Biological

KW - Tissue Engineering/methods

U2 - 10.1016/j.jtbi.2015.12.020

DO - 10.1016/j.jtbi.2015.12.020

M3 - Article

C2 - 26796221

SN - 0022-5193

VL - 394

SP - 149

EP - 159

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

ER -

The influence of hydrostatic pressure on tissue engineered bone development

Abstract

Keywords

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