Abstract
The mechanistic target of rapamycin (mTOR) is a central regulator of muscle protein synthesis, and its activation has long been attributed to its translocation to the lysosome. Here, we present a novel model of mTOR activation in skeletal muscle where the translocation of mTOR and the lysosome toward the cell membrane is a key process in mTOR activation.
| Original language | English |
|---|---|
| Pages (from-to) | 46-53 |
| Number of pages | 8 |
| Journal | Exercise and Sport Sciences Reviews |
| Volume | 47 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2019 |
Bibliographical note
Publisher Copyright:© Lippincott Williams & Wilkins.
Keywords
- amino acids
- lysosome
- mTORC1
- resistance exercise
- skeletal muscle
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
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