TY - JOUR
T1 - The impact of peroxisomes on cellular aging and death
AU - Manivannan, Selvambigai
AU - Scheckhuber, Christian Quintus
AU - Veenhuis, Marten
AU - van der Klei, Ida Johanna
PY - 2012/5/21
Y1 - 2012/5/21
N2 - Peroxisomes are ubiquitous eukaryotic organelles, which perform a plethora of functions including hydrogen peroxide metabolism and β-oxidation of fatty acids. Reactive oxygen species produced by peroxisomes are a major contributing factor to cellular oxidative stress, which is supposed to significantly accelerate aging and cell death according to the free radical theory of aging. However, relative to mitochondria, the role of the other oxidative organelles, the peroxisomes, in these degenerative pathways has not been extensively investigated. In this contribution we discuss our current knowledge on the role of peroxisomes in aging and cell death, with focus on studies performed in yeast.
AB - Peroxisomes are ubiquitous eukaryotic organelles, which perform a plethora of functions including hydrogen peroxide metabolism and β-oxidation of fatty acids. Reactive oxygen species produced by peroxisomes are a major contributing factor to cellular oxidative stress, which is supposed to significantly accelerate aging and cell death according to the free radical theory of aging. However, relative to mitochondria, the role of the other oxidative organelles, the peroxisomes, in these degenerative pathways has not been extensively investigated. In this contribution we discuss our current knowledge on the role of peroxisomes in aging and cell death, with focus on studies performed in yeast.
KW - aging
KW - autophagy
KW - cell death
KW - peroxisome
KW - yeast
U2 - 10.3389/fonc.2012.00050
DO - 10.3389/fonc.2012.00050
M3 - Article
C2 - 22662318
SN - 2234-943X
VL - 2
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 00050
ER -