The impact of peroxisomes on cellular aging and death

Selvambigai Manivannan, Christian Quintus Scheckhuber, Marten Veenhuis, Ida Johanna van der Klei

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Abstract

Peroxisomes are ubiquitous eukaryotic organelles, which perform a plethora of functions including hydrogen peroxide metabolism and β-oxidation of fatty acids. Reactive oxygen species produced by peroxisomes are a major contributing factor to cellular oxidative stress, which is supposed to significantly accelerate aging and cell death according to the free radical theory of aging. However, relative to mitochondria, the role of the other oxidative organelles, the peroxisomes, in these degenerative pathways has not been extensively investigated. In this contribution we discuss our current knowledge on the role of peroxisomes in aging and cell death, with focus on studies performed in yeast.

Original languageEnglish
Article number00050
JournalFrontiers in Oncology
Volume2
DOIs
Publication statusPublished - 5 Dec 2012

Keywords

  • aging
  • autophagy
  • cell death
  • peroxisome
  • yeast

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