The impact of pancreatic beta cell heterogeneity on type 1 diabetes pathogenesis

Richard K. P. Benninger; Craig Dorrell; David Hodson; Gary A. Rutter

doi:10.1007/s11892-018-1085-2

The impact of pancreatic beta cell heterogeneity on type 1 diabetes pathogenesis

Richard K. P. Benninger, Craig Dorrell, David Hodson, Gary A. Rutter

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

168 Downloads (Pure)

Abstract

Purpose of review: To discuss advances in our understanding of β cell heterogeneity and the ramifications of this for type 1 diabetes (T1D) and its therapy.

Recent findings: A number of studies have challenged the long-standing dogma that the majority of beta cells are eliminated in T1D. As many as 80% are present in some T1D subjects. Why don't these cells function properly to release insulin in response to high glucose? Other findings deploying single cell "omics" to study both healthy and diseased cells - from patients with both T1D and type 2 diabetes (T2D) - have revealed cell subpopulations and heterogeneity at the transcriptomic/protein level between individual cells. Finally, our own and others' findings have demonstrated the importance of functional beta cell sub-populations for insulin secretion.

Summary: Heterogeneity may endow beta cells with molecular features that predispose them to failure/death during T1D.

Original language	English
Article number	112
Journal	Current Diabetes Reports
Volume	18
Issue number	11
Early online date	24 Sept 2018
DOIs	https://doi.org/10.1007/s11892-018-1085-2
Publication status	Published - Nov 2018

Keywords

beta cell
type 1 diabetes
insulin
heterogeneity
transcriptomics
imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s11892-018-1085-2Licence: Creative Commons: Attribution (CC BY)

Benninger_et_al_The_impact_of_pancreatic_beta_cell_Current_Diabetes_Reports_2018Final published version, 1.34 MBLicence: Creative Commons: Attribution (CC BY)

https://link.springer.com/article/10.1007/s11892-018-1085-2Licence: Creative Commons: Attribution (CC BY)

Cite this

@article{4ef5838bc29942c1b3cf6b1056924887,

title = "The impact of pancreatic beta cell heterogeneity on type 1 diabetes pathogenesis",

abstract = "Purpose of review: To discuss advances in our understanding of β cell heterogeneity and the ramifications of this for type 1 diabetes (T1D) and its therapy.Recent findings: A number of studies have challenged the long-standing dogma that the majority of beta cells are eliminated in T1D. As many as 80% are present in some T1D subjects. Why don't these cells function properly to release insulin in response to high glucose? Other findings deploying single cell {"}omics{"} to study both healthy and diseased cells - from patients with both T1D and type 2 diabetes (T2D) - have revealed cell subpopulations and heterogeneity at the transcriptomic/protein level between individual cells. Finally, our own and others' findings have demonstrated the importance of functional beta cell sub-populations for insulin secretion.Summary: Heterogeneity may endow beta cells with molecular features that predispose them to failure/death during T1D. ",

keywords = "beta cell, type 1 diabetes, insulin, heterogeneity, transcriptomics, imaging",

author = "Benninger, {Richard K. P.} and Craig Dorrell and David Hodson and Rutter, {Gary A.}",

year = "2018",

month = nov,

doi = "10.1007/s11892-018-1085-2",

language = "English",

volume = "18",

journal = "Current Diabetes Reports",

issn = "1534-4827",

publisher = "Springer",

number = "11",

}

TY - JOUR

T1 - The impact of pancreatic beta cell heterogeneity on type 1 diabetes pathogenesis

AU - Benninger, Richard K. P.

AU - Dorrell, Craig

AU - Hodson, David

AU - Rutter, Gary A.

PY - 2018/11

Y1 - 2018/11

N2 - Purpose of review: To discuss advances in our understanding of β cell heterogeneity and the ramifications of this for type 1 diabetes (T1D) and its therapy.Recent findings: A number of studies have challenged the long-standing dogma that the majority of beta cells are eliminated in T1D. As many as 80% are present in some T1D subjects. Why don't these cells function properly to release insulin in response to high glucose? Other findings deploying single cell "omics" to study both healthy and diseased cells - from patients with both T1D and type 2 diabetes (T2D) - have revealed cell subpopulations and heterogeneity at the transcriptomic/protein level between individual cells. Finally, our own and others' findings have demonstrated the importance of functional beta cell sub-populations for insulin secretion.Summary: Heterogeneity may endow beta cells with molecular features that predispose them to failure/death during T1D.

AB - Purpose of review: To discuss advances in our understanding of β cell heterogeneity and the ramifications of this for type 1 diabetes (T1D) and its therapy.Recent findings: A number of studies have challenged the long-standing dogma that the majority of beta cells are eliminated in T1D. As many as 80% are present in some T1D subjects. Why don't these cells function properly to release insulin in response to high glucose? Other findings deploying single cell "omics" to study both healthy and diseased cells - from patients with both T1D and type 2 diabetes (T2D) - have revealed cell subpopulations and heterogeneity at the transcriptomic/protein level between individual cells. Finally, our own and others' findings have demonstrated the importance of functional beta cell sub-populations for insulin secretion.Summary: Heterogeneity may endow beta cells with molecular features that predispose them to failure/death during T1D.

KW - beta cell

KW - type 1 diabetes

KW - insulin

KW - heterogeneity

KW - transcriptomics

KW - imaging

U2 - 10.1007/s11892-018-1085-2

DO - 10.1007/s11892-018-1085-2

M3 - Article

C2 - 30251179

SN - 1534-4827

VL - 18

JO - Current Diabetes Reports

JF - Current Diabetes Reports

IS - 11

M1 - 112

ER -

The impact of pancreatic beta cell heterogeneity on type 1 diabetes pathogenesis

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this