The impact of cannabinoid receptor 2 deficiency on neutrophil recruitment and inflammation

Mohammed Tayab Hussain, David R. Greaves, Asif Jilani Iqbal

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
128 Downloads (Pure)

Abstract

Neutrophil trafficking into damaged or infected tissues is essential for the initiation of inflammation, clearance of pathogens and damaged cells, and ultimately tissue repair. Neutrophil recruitment is highly dependent on the stepwise induction of adhesion molecules and promigratory chemokines and cytokines. A number of studies in animal models have shown the efficacy of cannabinoid receptor 2 (CB2) agonists in limiting inflammation in a range of preclinical models of inflammation, including colitis, atherosclerosis, multiple sclerosis, and ischemia-reperfusion injury. Recent work in preclinical models of inflammation raises two questions: by what mechanisms do CB2 agonists provide anti-inflammatory effects during acute inflammation and what challenges exist in the translation of CB2 modulating therapeutics into the clinic.

Original languageEnglish
Pages (from-to)1025-1029
Number of pages5
JournalDNA and Cell Biology
Volume38
Issue number10
Early online dateSep 2019
DOIs
Publication statusPublished - Oct 2019

Keywords

  • neutrophils
  • inflammation
  • cannabinoids
  • cannabinoid receptors

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