The immune system and schizophrenia: An update for clinicians

Rachel Upthegrove*, Nicholas M. Barnes

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)
    1100 Downloads (Pure)


    It has long been recognised that the pathology of schizophrenia may involve the immune system, yet this has been a relatively neglected area of research. Recent advances in our understanding of the complexities and functioning of the immune system have allowed new investigation into this area from many angles, including cellular and genetic avenues. A number of prominent theories have been developed. This article gives an overview of our understanding of the immune system and highlights recent advances pertaining to schizophrenia. LEARNING OBJECTIVES: • To refresh and update understanding of the innate and adaptive immune system, presented clearly to the non-expert audience. • To understand key advances in immunological theories of schizophrenia. • To engender clinicians' enthusiasm for further reading and interest in this topic.

    Original languageEnglish
    Pages (from-to)83-91
    Number of pages9
    JournalAdvances in Psychiatric Treatment
    Issue number2
    Publication statusPublished - 1 Jan 2014

    ASJC Scopus subject areas

    • Psychiatry and Mental health


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