The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13

Simon Jones; G Watkins; N Le Good; S Roberts; C L Murphy; S M V Brockbank; M R C Needham; S J Read; P Newham

doi:10.1016/j.joca.2008.09.012

The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13

Simon Jones
, G Watkins
, N Le Good
, S Roberts
, C L Murphy
, S M V Brockbank
, M R C Needham
, S J Read
, P Newham

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

262 Citations (Scopus)

Abstract

To identify differentially expressed microRNAs (miRNAs) in human osteoarthritic (OA) cartilage and bone tissue and to determine their relevance to chondrocyte function.

Original language	English
Pages (from-to)	464-72
Number of pages	9
Journal	Osteoarthritis and Cartilage
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.joca.2008.09.012
Publication status	Published - Apr 2009

Keywords

Tumor Necrosis Factor-alpha
MicroRNAs
Humans
Cartilage, Articular
Aged
Chondrocytes
Matrix Metalloproteinase 13
Computational Biology
Gene Expression Profiling
Osteoarthritis, Knee
Cells, Cultured
Inflammation Mediators
Gene Expression Regulation
Middle Aged
Signal Transduction

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10.1016/j.joca.2008.09.012

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title = "The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13",

abstract = "To identify differentially expressed microRNAs (miRNAs) in human osteoarthritic (OA) cartilage and bone tissue and to determine their relevance to chondrocyte function.",

keywords = "Tumor Necrosis Factor-alpha, MicroRNAs, Humans, Cartilage, Articular, Aged, Chondrocytes, Matrix Metalloproteinase 13, Computational Biology, Gene Expression Profiling, Osteoarthritis, Knee, Cells, Cultured, Inflammation Mediators, Gene Expression Regulation, Middle Aged, Signal Transduction",

author = "Simon Jones and G Watkins and \{Le Good\}, N and S Roberts and Murphy, \{C L\} and Brockbank, \{S M V\} and Needham, \{M R C\} and Read, \{S J\} and P Newham",

year = "2009",

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doi = "10.1016/j.joca.2008.09.012",

language = "English",

volume = "17",

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T1 - The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13

AU - Jones, Simon

AU - Watkins, G

AU - Le Good, N

AU - Roberts, S

AU - Murphy, C L

AU - Brockbank, S M V

AU - Needham, M R C

AU - Read, S J

AU - Newham, P

PY - 2009/4

Y1 - 2009/4

N2 - To identify differentially expressed microRNAs (miRNAs) in human osteoarthritic (OA) cartilage and bone tissue and to determine their relevance to chondrocyte function.

AB - To identify differentially expressed microRNAs (miRNAs) in human osteoarthritic (OA) cartilage and bone tissue and to determine their relevance to chondrocyte function.

KW - Tumor Necrosis Factor-alpha

KW - MicroRNAs

KW - Humans

KW - Cartilage, Articular

KW - Aged

KW - Chondrocytes

KW - Matrix Metalloproteinase 13

KW - Computational Biology

KW - Gene Expression Profiling

KW - Osteoarthritis, Knee

KW - Cells, Cultured

KW - Inflammation Mediators

KW - Gene Expression Regulation

KW - Middle Aged

KW - Signal Transduction

U2 - 10.1016/j.joca.2008.09.012

DO - 10.1016/j.joca.2008.09.012

M3 - Article

C2 - 19008124

SN - 1522-9653

VL - 17

SP - 464

EP - 472

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

IS - 4

ER -

The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13

Abstract

Keywords

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