The Human Mucosal Mycobiome and Fungal Community Interactions

Elizabeth Witherden, Saeed Shoaie, Rebecca Hall, David Moyes

Research output: Contribution to journalSpecial issuepeer-review

19 Citations (Scopus)
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With the advent of high-throughput sequencing techniques, the astonishing extent and complexity of the microbial communities that reside within and upon us has begun to become clear. Moreover, with advances in computing and modelling methods, we are now beginning to grasp just how dynamic our interactions with these communities are. The diversity of both these communities and their interactions—both within the community and with us—are dependent on a multitude of factors, both microbial- and host-mediated. Importantly, it is becoming clear that shifts in the makeup of these communities, or their responses, are linked to different disease states. Although much of the work to define these interactions and links has been investigating bacterial communities, recently there has been significant growth in the body of knowledge, indicating that shifts in the host fungal communities (mycobiome) are also intimately linked to disease status. In this review, we will explore these associations, along with the interactions between fungal communities and their human and microbial habitat, and discuss the future applications of systems biology in determining their role in disease status.
Original languageEnglish
Article number56
JournalJournal of Fungi
Issue number4
Early online date7 Oct 2017
Publication statusE-pub ahead of print - 7 Oct 2017


  • mycobiome
  • bacterial-fungal interactions
  • fungal-fungal interactions
  • hostfungal interactions
  • systems biology


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