The human fetal adrenal cortex and the window of sexual differentiation

NA Hanley, Wiebke Arlt

    Research output: Contribution to journalReview article

    30 Citations (Scopus)


    Understanding normal development is fundamental to appreciating postnatal morphology, physiology and, in some instances, pathophysiology. Developmental biology tends to interrogate models in nonprimate species, for instance the mouse, where genetic manipulation gives privileged insight into the function of particular genes. Some human developmental processes, as occur in the adrenal gland, are not faithfully reproduced in these rodent models, yet have an impact on the pathophysiology and treatment of endocrine disorders, such as congenital adrenal hyperplasia. In this setting, in vitro research of normal human development complements clinical investigation of patients born with congenital disorders.
    Original languageEnglish
    Pages (from-to)391-7
    Number of pages7
    JournalTrends in Endocrinology and Metabolism
    VolumeAhead of print
    Publication statusPublished - 1 Dec 2006


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