Abstract
ESAT-6 is a well characterized secreted protein from Mycobacterium tuberculosis and represents the archetype of the WXG100 family of proteins. Genes encoding ESAT-6 homologues have been identified in the genome of the human pathogen Streptococcus agalactiae; one of these genes, esxA, has been cloned and the recombinant protein has been crystallized. In contrast to M. tuberculosis ESAT-6, the crystal structure of GBS1074 reveals a homodimeric structure similar to homologous structures from Staphylococcus aureus and Helicobacter pylori. Intriguingly, GBS1074 forms elongated fibre-like assemblies in the crystal structure.
Original language | English |
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Pages (from-to) | 1421-1425 |
Number of pages | 5 |
Journal | Acta Crystallographica Section F Structural Biology and Crystallization Communications |
Volume | 66 |
DOIs | |
Publication status | Published - 1 Nov 2010 |
Keywords
- ESAT-6
- WXG100
- GBS1074
- four-helix bundle