The homodimeric GBS1074 from Streptococcus agalactiae

Anshuman Shukla, Mark Pallen, M Anthony, Scott White

Research output: Contribution to journalArticle

13 Citations (Scopus)


ESAT-6 is a well characterized secreted protein from Mycobacterium tuberculosis and represents the archetype of the WXG100 family of proteins. Genes encoding ESAT-6 homologues have been identified in the genome of the human pathogen Streptococcus agalactiae; one of these genes, esxA, has been cloned and the recombinant protein has been crystallized. In contrast to M. tuberculosis ESAT-6, the crystal structure of GBS1074 reveals a homodimeric structure similar to homologous structures from Staphylococcus aureus and Helicobacter pylori. Intriguingly, GBS1074 forms elongated fibre-like assemblies in the crystal structure.
Original languageEnglish
Pages (from-to)1421-1425
Number of pages5
JournalActa Crystallographica Section F Structural Biology and Crystallization Communications
Publication statusPublished - 1 Nov 2010


  • ESAT-6
  • WXG100
  • GBS1074
  • four-helix bundle


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