The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents

Teresa Carlomagno; Marcel J J Blommers; Jens Meiler; Wolfgang Jahnke; Thomas Schupp; Frank Petersen; Dieter Schinzer; Karl-Heinz Altmann; Christian Griesinger

doi:10.1002/anie.200351276

The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents

Teresa Carlomagno, Marcel J J Blommers, Jens Meiler, Wolfgang Jahnke, Thomas Schupp, Frank Petersen, Dieter Schinzer, Karl-Heinz Altmann, Christian Griesinger

Biosciences

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	2511-5
Number of pages	5
Journal	Angewandte Chemie (International Edition)
Volume	42
Issue number	22
DOIs	https://doi.org/10.1002/anie.200351276
Publication status	Published - 6 Jun 2003

Keywords

Animals
Antineoplastic Agents/chemistry
Cattle
Epothilones/chemistry
Models, Molecular
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Solutions/chemistry
Structure-Activity Relationship
Tubulin/chemistry

Access to Document

10.1002/anie.200351276

Cite this

Carlomagno, T., Blommers, M. J. J., Meiler, J., Jahnke, W., Schupp, T., Petersen, F., Schinzer, D., Altmann, K.-H., & Griesinger, C. (2003). The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents. Angewandte Chemie (International Edition) , 42(22), 2511-5. https://doi.org/10.1002/anie.200351276

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title = "The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents",

keywords = "Animals, Antineoplastic Agents/chemistry, Cattle, Epothilones/chemistry, Models, Molecular, Molecular Conformation, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Solutions/chemistry, Structure-Activity Relationship, Tubulin/chemistry",

author = "Teresa Carlomagno and Blommers, {Marcel J J} and Jens Meiler and Wolfgang Jahnke and Thomas Schupp and Frank Petersen and Dieter Schinzer and Karl-Heinz Altmann and Christian Griesinger",

year = "2003",

month = jun,

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Carlomagno, T, Blommers, MJJ, Meiler, J, Jahnke, W, Schupp, T, Petersen, F, Schinzer, D, Altmann, K-H & Griesinger, C 2003, 'The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents', Angewandte Chemie (International Edition) , vol. 42, no. 22, pp. 2511-5. https://doi.org/10.1002/anie.200351276

The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents. / Carlomagno, Teresa; Blommers, Marcel J J; Meiler, Jens et al.
In: Angewandte Chemie (International Edition) , Vol. 42, No. 22, 06.06.2003, p. 2511-5.

Research output: Contribution to journal › Article › peer-review

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AU - Petersen, Frank

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AU - Griesinger, Christian

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KW - Antineoplastic Agents/chemistry

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KW - Epothilones/chemistry

KW - Models, Molecular

KW - Molecular Conformation

KW - Molecular Structure

KW - Nuclear Magnetic Resonance, Biomolecular

KW - Solutions/chemistry

KW - Structure-Activity Relationship

KW - Tubulin/chemistry

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