The hidden cost of modern medical interventions: how medical advances have shaped the prevalence of human fungal disease

Callum Clark; Rebecca Drummond

doi:10.3390/pathogens8020045

The hidden cost of modern medical interventions: how medical advances have shaped the prevalence of human fungal disease

Immunology and Immunotherapy

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

233 Downloads (Pure)

Abstract

Life expectancy in the West is the highest it has ever been, due to the introduction of better hygiene practices and sophisticated medical interventions for cancer, autoimmunity and infectious disease. With these modern advances, a rise in the prevalence of opportunistic infections has also been observed. These include several fungal infections, which present a particular clinical challenge due to the lack of fungal vaccines, limited diagnostics and increasing antifungal drug resistance. This mini-review outlines how modern-day clinical practices have shaped the recent increase in fungal diseases observed in the last few decades. We discuss new research that has implicated the use of immune-modulating drugs in the enhanced susceptibility of vulnerable patients to life-threatening fungal infections.

Original language	English
Article number	45
Pages (from-to)	1-11
Number of pages	11
Journal	Pathogens
Volume	8
Issue number	2
DOIs	https://doi.org/10.3390/pathogens8020045
Publication status	Published - 4 Apr 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aspergillus
Candida
antibiotics
corticosteroids
fungi
ibrutinib
macrophage

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10.3390/pathogens8020045Licence: Creative Commons: Attribution (CC BY)

pathogens-08-00045
Clark, C & Drummond, R. (2019) 'The hidden cost of modern medical interventions: how medical advances have shaped the prevalence of human fungal disease', Pathogens, vol. 8, no. 2, 45, pp. 1-11. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. https://doi.org/10.3390/pathogens8020045
Final published version, 747 KBLicence: Creative Commons: Attribution (CC BY)

https://www.mdpi.com/2076-0817/8/2/45Licence: Creative Commons: Attribution (CC BY)

Cite this

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The hidden cost of modern medical interventions: how medical advances have shaped the prevalence of human fungal disease

Abstract

UN SDGs

Keywords

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