The genetics of chronic obstructive pulmonary disease

Alice Turner, Robert Stockley

Research output: Contribution to journalReview articlepeer-review

59 Citations (Scopus)
155 Downloads (Pure)

Abstract

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease caused by the interaction of genetic susceptibility and environmental influences. There is increasing evidence that genes link to disease pathogenesis and heterogeneity by causing variation in protease anti-protease systems, defence against oxidative stress and inflammation. The main methods of genomic research for complex disease traits are described, together with the genes implicated in COPD thus far, their roles in disease causation and the future for this area of investigation.
Original languageEnglish
Pages (from-to)130
Number of pages1
JournalRespiratory research
Volume7
DOIs
Publication statusPublished - 20 Oct 2006

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