The First Synthesis of the Sterically Encumbered Adamantoid Phosphazane P4(NtBu)6: Enabled by Mechanochemistry

Yan X. Shi; Kai Xu; Jack K. Clegg; Rakesh Ganguly; Hajime Hirao; Tomislav Friščić; Felipe García

doi:10.1002/anie.201605936

The First Synthesis of the Sterically Encumbered Adamantoid Phosphazane P₄(N^tBu)₆: Enabled by Mechanochemistry

Yan X. Shi
, Kai Xu
, Jack K. Clegg
, Rakesh Ganguly
, Hajime Hirao
, Tomislav Friščić
, Felipe García^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

All reported attempts to synthesize the tert-butyl-substituted adamantoid phosph(III)azane P₄(N^tBu)₆have failed, leading to the classification of this molecule as inaccessible and a literature example of steric control in chemistry of phosphorus-nitrogen compounds. We now demonstrate that this structure is readily accessible by a solvent-free mechanochemical milling approach, highlighting the importance of mechanochemical reaction environments in evaluating chemical reactivity.

Original language	English
Pages (from-to)	12736-12740
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	55
Issue number	41
DOIs	https://doi.org/10.1002/anie.201605936
Publication status	Published - 4 Oct 2016

Bibliographical note

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

green chemistry
main-group chemistry
mechanochemistry
phosphazanes
rearrangements

ASJC Scopus subject areas

Catalysis
General Chemistry

Access to Document

10.1002/anie.201605936

Cite this

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abstract = "All reported attempts to synthesize the tert-butyl-substituted adamantoid phosph(III)azane P4(NtBu)6have failed, leading to the classification of this molecule as inaccessible and a literature example of steric control in chemistry of phosphorus-nitrogen compounds. We now demonstrate that this structure is readily accessible by a solvent-free mechanochemical milling approach, highlighting the importance of mechanochemical reaction environments in evaluating chemical reactivity.",

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AU - Friščić, Tomislav

AU - García, Felipe

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