TY - JOUR
T1 - The evolution of the protein corona around nanoparticles
T2 - A test study
AU - Lundqvist, M.
AU - Stigler, J.
AU - Lynch, I.
AU - Dawson, K.
AU - Cedervall, T.
AU - Berggård, T.
AU - Flanagan, M.B.
AU - Elia, G.
N1 - Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/9/27
Y1 - 2011/9/27
N2 - The importance of the protein corona formed around nanoparticles upon entering a biological fluid has recently been highlighted. This corona is, when sufficiently long-lived, thought to govern the particles' biological fate. However, even this long-lived "hard" corona evolves and re-equilibrates as particles pass from one biological fluid to another, and may be an important feature for long-term fate. Here we show the evolution of the protein corona as a result of transfer of nanoparticles from one biological fluid (plasma) into another (cytosolic fluid), a simple illustrative model for the uptake of nanoparticles into cells. While no direct comparison can be made to what would happen in, for example, the uptake pathway, the results confirm that significant evolution of the corona occurs in the second biological solution, but that the final corona contains a "fingerprint" of its history. This could be evolved to map the transport pathways utilized by nanoparticles, and eventually to predict nanoparticle fate and behavior.
AB - The importance of the protein corona formed around nanoparticles upon entering a biological fluid has recently been highlighted. This corona is, when sufficiently long-lived, thought to govern the particles' biological fate. However, even this long-lived "hard" corona evolves and re-equilibrates as particles pass from one biological fluid to another, and may be an important feature for long-term fate. Here we show the evolution of the protein corona as a result of transfer of nanoparticles from one biological fluid (plasma) into another (cytosolic fluid), a simple illustrative model for the uptake of nanoparticles into cells. While no direct comparison can be made to what would happen in, for example, the uptake pathway, the results confirm that significant evolution of the corona occurs in the second biological solution, but that the final corona contains a "fingerprint" of its history. This could be evolved to map the transport pathways utilized by nanoparticles, and eventually to predict nanoparticle fate and behavior.
UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-80053313445&md5=d813575924a1fd4ca21e60fcb5dbf7f9
U2 - 10.1021/nn202458g
DO - 10.1021/nn202458g
M3 - Article
AN - SCOPUS:80053313445
SN - 1936-0851
VL - 5
SP - 7503
EP - 7509
JO - ACS Nano
JF - ACS Nano
IS - 9
ER -