Abstract
The N-end rule pathway of targeted proteolysis, which relates the stability of a protein to the nature of its N-terminus, has emerged as a key regulator of diverse processes in eukaryotes. Recent reports that N-terminally acetylated and methionine-initiating proteins can be targeted for degradation have uncovered novel branches of the pathway, and a wide range of protein substrates has now been identified in animals, fungi, and plants. Of particular interest is the finding that the N-end rule pathway mediates oxygen and nitric oxide (NO) sensing in plants and animals by controlling the stability of kingdom-specific substrates. These findings highlight how conserved degradation mechanisms of the N-end rule pathway underlie functional divergence throughout eukaryotes.
Original language | English |
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Pages (from-to) | 603-11 |
Number of pages | 9 |
Journal | Trends in Cell Biology |
Volume | 24 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 2014 |
Bibliographical note
Copyright © 2014 Elsevier Ltd. All rights reserved.Keywords
- Animals
- Biodiversity
- Conserved Sequence
- Humans
- Plants
- Protein Processing, Post-Translational