TY - JOUR
T1 - The epidemiology of aggresssive pituitary tumors (and its challenges)
AU - Dekkers, Olaf
AU - Karavitaki, Niki
AU - Pereira, Alberto
PY - 2020/5/2
Y1 - 2020/5/2
N2 - Pituitary tumors are not rare if prevalence rates from autopsy or radiological series are considered; approximately 0.5% of all pituitary adenomas will come to medical attention. Less than 0.1% of these pituitary adenomas will become malignant, and probably around 0.5% of all detected adenomas will display an aggressive course. However, the exact incidence of both aggressive pituitary adenomas and pituitary carcinomas is unknown, as most data come from series with selected patients, such as surgically treated patients, which is likely not a reflection of all patients with a pituitary adenoma. An aggressive pituitary adenoma is not well-defined; even though an overarching definition, capturing both immunohistochemical and clinical characteristics is probably not waterproof, adoption of a widely accepted definition will be very helpful to harmonize research and establish more reliable epidemiological data.
AB - Pituitary tumors are not rare if prevalence rates from autopsy or radiological series are considered; approximately 0.5% of all pituitary adenomas will come to medical attention. Less than 0.1% of these pituitary adenomas will become malignant, and probably around 0.5% of all detected adenomas will display an aggressive course. However, the exact incidence of both aggressive pituitary adenomas and pituitary carcinomas is unknown, as most data come from series with selected patients, such as surgically treated patients, which is likely not a reflection of all patients with a pituitary adenoma. An aggressive pituitary adenoma is not well-defined; even though an overarching definition, capturing both immunohistochemical and clinical characteristics is probably not waterproof, adoption of a widely accepted definition will be very helpful to harmonize research and establish more reliable epidemiological data.
KW - Aggressive pituitary adenoma
KW - Carcinoma
KW - Epidemiology
KW - Incidence
UR - http://www.scopus.com/inward/record.url?scp=85085112282&partnerID=8YFLogxK
U2 - 10.1007/s11154-020-09556-7
DO - 10.1007/s11154-020-09556-7
M3 - Review article
SN - 1389-9155
VL - 21
SP - 209
EP - 212
JO - Reviews in endocrine & metabolic disorders
JF - Reviews in endocrine & metabolic disorders
IS - 2
ER -