The emerging roles of ribosomal histidyl hydroxylases in cell biology, physiology and disease

James R Bundred, Eline Hendrix, Mathew L Coleman

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)
103 Downloads (Pure)

Abstract

Hydroxylation is a novel protein modification catalyzed by a family of oxygenases that depend on fundamental nutrients and metabolites for activity. Protein hydroxylases have been implicated in a variety of key cellular processes that play important roles in both normal homeostasis and pathogenesis. Here, in this review, we summarize the current literature on a highly conserved sub-family of oxygenases that catalyze protein histidyl hydroxylation. We discuss the evidence supporting the biochemical assignment of these emerging enzymes as ribosomal protein hydroxylases, and provide an overview of their role in immunology, bone development, and cancer.

Original languageEnglish
Pages (from-to)4093-4105
Number of pages13
JournalCellular and Molecular Life Sciences
Volume75
Issue number22
Early online date27 Aug 2018
DOIs
Publication statusPublished - Nov 2018

Keywords

  • Animals
  • Histone Demethylases/metabolism
  • Humans
  • Mixed Function Oxygenases/chemistry
  • Muscle, Skeletal/growth & development
  • Neoplasms/immunology
  • Nuclear Proteins/metabolism
  • Protein Processing, Post-Translational
  • Ribosomal Proteins/chemistry
  • Ribosomes/enzymology

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