Abstract
It is now 10 years since PTTG was first cloned and isolated. Perhaps the major story of the intervening decade of work performed by numerous groups around the world is the sheer multifunctionality ascribed to this gene. PTTG has been implicated in mechanisms of gene transactivation, cell transformation, angiogenesis, metabolism, apoptosis, DNA repair, genetic instability and mitotic control, both in endocrine and non-endocrine settings. In the current review, we cast a critical eye over a decade of PTTG research within the field of endocrine neoplasia.
Original language | English |
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Pages (from-to) | 1-6 |
Number of pages | 6 |
Journal | Molecular and Cellular Endocrinology |
Volume | 278 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 15 Nov 2007 |
Keywords
- securin
- endocrine cancer
- PTTG