The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism

Rachel S Fletcher, Gareth G Lavery

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)
152 Downloads (Pure)

Abstract

The concept of replenishing or elevating NAD+ availability to combat metabolic disease and ageing is an area of intense research. This has led to a need to define the endogenous regulatory pathways and mechanisms cells and tissues utilise to maximise NAD+ availability such that strategies to intervene in the clinical setting are able to be fully realised. This review discusses the importance of different salvage pathways involved in metabolising the vitamin B3 class of NAD+ precursor molecules, with a particular focus on the recently identified nicotinamide riboside kinase pathway at both a tissue-specific and systemic level.

Original languageEnglish
Pages (from-to)R107-R121
JournalJournal of Molecular Endocrinology
Volume61
Issue number3
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • NAD+
  • metabolism
  • nicotinamide riboside
  • energy

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