The effects of Gilles de la Tourette syndrome and other chronic tic disorders on quality of life across the lifespan: a systematic review

Joel Evans, Stefano Seri, Andrea E. Cavanna

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)
128 Downloads (Pure)

Abstract

Gilles de la Tourette syndrome (GTS) and other chronic tic disorders are neurodevelopmental conditions characterized by the presence of tics and associated behavioral problems. Whilst converging evidence indicates that these conditions can affect patients’ quality of life (QoL), the extent of this impairment across the lifespan is not well understood. We conducted a systematic literature review of published QoL studies in GTS and other chronic tic disorders to comprehensively assess the effects of these conditions on QoL in different age groups. We found that QoL can be perceived differently by child and adult patients, especially with regard to the reciprocal contributions of tics and behavioral problems to the different domains of QoL. Specifically, QoL profiles in children often reflect the impact of co-morbid attention-deficit and hyperactivity symptoms, which tend to improve with age, whereas adults’ perception of QoL seems to be more strongly affected by the presence of depression and anxiety. Management strategies should take into account differences in age-related QoL needs between children and adults with GTS or other chronic tic disorders.
Original languageEnglish
Pages (from-to)939–948
JournalEuropean Child & Adolescent Psychiatry
Volume25
Issue number9
Early online date15 Feb 2016
DOIs
Publication statusPublished - Sep 2016

Keywords

  • Gilles de la Tourette syndrome
  • Tics
  • Behavior
  • Quality of life
  • Children
  • Adults

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