The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro

T J Mitchell; J M Ketley; D W Burdon; D C Candy; J Stephen

doi:10.1099/00222615-23-3-205

The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro

T J Mitchell, J M Ketley, D W Burdon, D C Candy, J Stephen

Microbes, Infection and Microbiomes

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Clostridium difficile toxins A and B inhibited protein synthesis in McCoy tissue-culture cells but not in intestinal cells in vitro or in vivo. Toxins A and B had no effect on membrane permeability of either intestinal cells or McCoy cells.

Original language	English
Pages (from-to)	205-10
Number of pages	6
Journal	Journal of Medical Microbiology
Volume	23
Issue number	3
DOIs	https://doi.org/10.1099/00222615-23-3-205
Publication status	Published - May 1987

Keywords

Alkaline Phosphatase
Animals
Bacterial Proteins
Bacterial Toxins
Cell Membrane Permeability
Cells, Cultured
Clostridium
Enterotoxins
In Vitro Techniques
Intestines
Protein Biosynthesis
Rabbits

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10.1099/00222615-23-3-205

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title = "The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro",

abstract = "Clostridium difficile toxins A and B inhibited protein synthesis in McCoy tissue-culture cells but not in intestinal cells in vitro or in vivo. Toxins A and B had no effect on membrane permeability of either intestinal cells or McCoy cells.",

keywords = "Alkaline Phosphatase, Animals, Bacterial Proteins, Bacterial Toxins, Cell Membrane Permeability, Cells, Cultured, Clostridium, Enterotoxins, In Vitro Techniques, Intestines, Protein Biosynthesis, Rabbits",

author = "Mitchell, \{T J\} and Ketley, \{J M\} and Burdon, \{D W\} and Candy, \{D C\} and J Stephen",

year = "1987",

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doi = "10.1099/00222615-23-3-205",

language = "English",

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pages = "205--10",

journal = "Journal of Medical Microbiology",

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publisher = "Microbiology Society",

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T1 - The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro

AU - Mitchell, T J

AU - Ketley, J M

AU - Burdon, D W

AU - Candy, D C

AU - Stephen, J

PY - 1987/5

Y1 - 1987/5

N2 - Clostridium difficile toxins A and B inhibited protein synthesis in McCoy tissue-culture cells but not in intestinal cells in vitro or in vivo. Toxins A and B had no effect on membrane permeability of either intestinal cells or McCoy cells.

AB - Clostridium difficile toxins A and B inhibited protein synthesis in McCoy tissue-culture cells but not in intestinal cells in vitro or in vivo. Toxins A and B had no effect on membrane permeability of either intestinal cells or McCoy cells.

KW - Alkaline Phosphatase

KW - Animals

KW - Bacterial Proteins

KW - Bacterial Toxins

KW - Cell Membrane Permeability

KW - Cells, Cultured

KW - Clostridium

KW - Enterotoxins

KW - In Vitro Techniques

KW - Intestines

KW - Protein Biosynthesis

KW - Rabbits

UR - https://www.scopus.com/pages/publications/0023244784

U2 - 10.1099/00222615-23-3-205

DO - 10.1099/00222615-23-3-205

M3 - Article

C2 - 3585957

SN - 0022-2615

VL - 23

SP - 205

EP - 210

JO - Journal of Medical Microbiology

JF - Journal of Medical Microbiology

IS - 3

ER -

The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro

Abstract

Keywords

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