The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro

T J Mitchell, J M Ketley, D W Burdon, D C Candy, J Stephen

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Clostridium difficile toxins A and B inhibited protein synthesis in McCoy tissue-culture cells but not in intestinal cells in vitro or in vivo. Toxins A and B had no effect on membrane permeability of either intestinal cells or McCoy cells.

Original languageEnglish
Pages (from-to)205-10
Number of pages6
JournalJournal of Medical Microbiology
Volume23
Issue number3
DOIs
Publication statusPublished - May 1987

Keywords

  • Alkaline Phosphatase
  • Animals
  • Bacterial Proteins
  • Bacterial Toxins
  • Cell Membrane Permeability
  • Cells, Cultured
  • Clostridium
  • Enterotoxins
  • In Vitro Techniques
  • Intestines
  • Protein Biosynthesis
  • Rabbits

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