TY - JOUR
T1 - The effect of saffron on weight and lipid profile
T2 - A systematic review, meta-analysis, and dose–response of randomized clinical trials
AU - Rahmani, Jamal
AU - Manzari, Nicla
AU - Thompson, Jacqueline
AU - Clark, Cain C.T.
AU - Villanueva, Gemma
AU - Varkaneh, Hamed Kord
AU - Mirmiran, Parvin
N1 - Publisher Copyright:
© 2019 John Wiley & Sons, Ltd.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Plant derivatives such as carotenoids and phytosterols enrich foods have been shown to reduce plasma triglyceride (TG), low-density lipoprotein (LDL) cholesterol, and cholesterol concentrations. The aim of this systematic review and meta-analyses study was to investigate the effects of saffron on lipid profiles, reported in randomized controlled trials (RCTs). We performed a systematic electronic search in PubMed/MEDLINE, Cochrane, and SCOPUS to identify RCTs and screening of relevant articles references up to October 12, 2018. There were no language restrictions. We performed this systematic review and meta-analysis according to the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses guidelines. We identified and analyzed 14 eligible studies in this meta-analysis. Our study found a significant reduction in cholesterol and TG following saffron intervention (weighted mean difference [WMD]: −6.36 mg/dl, 95% confidence interval, CI, [−10.58, −2.18] and WMD: −5.37 mg/dl, 95% CI [−10.25, −0.48], respectively). There was no significant effect on weight and LDL concentration. A meta-regression analysis showed that long-term saffron intervention can increase the high-density lipoprotein (HDL) levels. In conclusions, our study findings indicate some benefits of saffron on cholesterol, HDL, and TG compared with placebo. However, we recommend the conduct of adequately powered, high-quality RCTs with short- and long-term follow-up, evaluating relevant clinical outcomes to allow for making definitive recommendations.
AB - Plant derivatives such as carotenoids and phytosterols enrich foods have been shown to reduce plasma triglyceride (TG), low-density lipoprotein (LDL) cholesterol, and cholesterol concentrations. The aim of this systematic review and meta-analyses study was to investigate the effects of saffron on lipid profiles, reported in randomized controlled trials (RCTs). We performed a systematic electronic search in PubMed/MEDLINE, Cochrane, and SCOPUS to identify RCTs and screening of relevant articles references up to October 12, 2018. There were no language restrictions. We performed this systematic review and meta-analysis according to the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses guidelines. We identified and analyzed 14 eligible studies in this meta-analysis. Our study found a significant reduction in cholesterol and TG following saffron intervention (weighted mean difference [WMD]: −6.36 mg/dl, 95% confidence interval, CI, [−10.58, −2.18] and WMD: −5.37 mg/dl, 95% CI [−10.25, −0.48], respectively). There was no significant effect on weight and LDL concentration. A meta-regression analysis showed that long-term saffron intervention can increase the high-density lipoprotein (HDL) levels. In conclusions, our study findings indicate some benefits of saffron on cholesterol, HDL, and TG compared with placebo. However, we recommend the conduct of adequately powered, high-quality RCTs with short- and long-term follow-up, evaluating relevant clinical outcomes to allow for making definitive recommendations.
KW - cholesterol
KW - crocin
KW - LDL
KW - saffron
KW - triglyceride
KW - weight
UR - http://www.scopus.com/inward/record.url?scp=85068522051&partnerID=8YFLogxK
U2 - 10.1002/ptr.6420
DO - 10.1002/ptr.6420
M3 - Review article
C2 - 31264281
AN - SCOPUS:85068522051
SN - 0951-418X
VL - 33
SP - 2244
EP - 2255
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 9
ER -