Abstract
The effect of dantrolene on tetanic potentiation of MEPP frequency in salines containing 1 mM EGTA and no added Ca2+ has been examined. Dantrolene pre-treatment results in no significant change in the response of normalized MEPP frequency to tetanus at stimulation rates of both 25 and 100 Hz. This result is compared to the way in which dantrolene interacts with other agents that modify spontaneous release and it is suggested that intracellular Ca2+ movements during nerve tetanus may well be complex involving more than one Ca2+ store.
| Original language | English |
|---|---|
| Pages (from-to) | 321-4 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 253 |
| Issue number | 1-2 |
| Publication status | Published - 16 Dec 1982 |
Keywords
- Animals
- Dantrolene
- Egtazic Acid
- Electric Stimulation
- Ethylene Glycols
- Ion Channels
- Membrane Potentials
- Motor Endplate
- Muscle Contraction
- Neuromuscular Junction
- Rana temporaria
- Synaptic Transmission